延缓衰老的生活方式干预。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal Pub Date : 2023-11-03 DOI:10.1016/j.bj.2023.100676

Jan Martel , David M. Ojcius , John D. Young

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引用次数: 0

摘要

衰老是一种细胞周期停滞的情况，它会增加炎症，并导致衰老人体中慢性疾病的发展。虽然几种被描述为senolytics和senomorphics的化合物通过减轻衰老的负担来产生健康益处，但对产生类似效果的生活方式干预的关注较少。我们在这里描述了运动、营养、热量限制、间歇性禁食、天然产物中的植物化学物质、益生元和益生菌以及充足的睡眠对模型生物和人类衰老的影响。这些干预措施可以整合到健康的生活方式中，以减少衰老和炎症，并延缓衰老的后果。

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Lifestyle interventions to delay senescence

Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body. While several compounds described as senolytics and senomorphics produce health benefits by reducing the burden of senescence, less attention has been devoted to lifestyle interventions that produce similar effects. We describe here the effects of exercise, nutrition, caloric restriction, intermittent fasting, phytochemicals from natural products, prebiotics and probiotics, and adequate sleep on senescence in model organisms and humans. These interventions can be integrated within a healthy lifestyle to reduce senescence and inflammation and delay the consequences of aging.

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来源期刊

Biomedical Journal Medicine-General Medicine

CiteScore

11.60

自引率

1.80%

发文量

128

审稿时长

42 days

期刊介绍： Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs. Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology. A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.