Shamim Ahmed Shamim, Naresh Kumar, Geetanjali Arora, Sahil Jaswal, Shalimar, Shivanand Gamanagatti, Chandrasekhar Bal
{"title":"一项68Ga PSMA PET/CT成像对传统成像诊断的HCC的前瞻性研究，以评估177Lu PSMA治疗的潜力。","authors":"Shamim Ahmed Shamim, Naresh Kumar, Geetanjali Arora, Sahil Jaswal, Shalimar, Shivanand Gamanagatti, Chandrasekhar Bal","doi":"10.1007/s12149-023-01876-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>PSMA expression is seen in many solid tumours in addition to prostate cancer and several studies and case reports have shown PSMA expression and <sup>68</sup>Ga-PSMA imaging of hepatocellular carcinoma (HCC). Our prospective study evaluates the role of <sup>68</sup>Ga-PSMA in HCC patients and compares it to conventional imaging (CE-CT/MRI).</p><p><strong>Methods: </strong>Patients with radiologically and/or histopathologically confirmed HCC were included and all had undergone serum alpha-fetoprotein (S.AFP) assessment as well as CE-CT/MRI prior to PSMA PET/CT. Acquired whole-body PET/CTs were analysed both visually and quantitatively by two experienced nuclear medicine physicians.</p><p><strong>Results: </strong>Forty-one (41) patients (36 male; 5 female) with known HCC and a mean age of 53.9 ± 10.9 years underwent <sup>68</sup>Ga-PSMA PET/CT. All patients had lesions on conventional imaging but only 38/41 patients showed <sup>68</sup>Ga-PSMA uptake. Conventional imaging revealed 18 patients with single lesions, all of which were tracer avid. Twenty-three (23) of 41 patients had multifocal (> 2) hepatic lesions on CE-CT/MRI of which 3 patients showed no <sup>68</sup>Ga-PSMA uptake, 7 showed tracer uptake in a single lesion only and 13 patients had multifocal tracer avid lesions. There was no correlation observed between S. AFP level and tumour SUV<sub>max</sub> on <sup>68</sup>Ga-PSMA PET/CT.</p><p><strong>Conclusion: </strong><sup>68</sup>Ga-PSMA PET/CT imaging of HCC may complement conventional imaging and identify patients for potential theranostic intervention.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A prospective study of <sup>68</sup>Ga-PSMA PET/CT imaging of HCC as diagnosed on conventional imaging to evaluate for potential <sup>177</sup>Lu-PSMA therapy.\",\"authors\":\"Shamim Ahmed Shamim, Naresh Kumar, Geetanjali Arora, Sahil Jaswal, Shalimar, Shivanand Gamanagatti, Chandrasekhar Bal\",\"doi\":\"10.1007/s12149-023-01876-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>PSMA expression is seen in many solid tumours in addition to prostate cancer and several studies and case reports have shown PSMA expression and <sup>68</sup>Ga-PSMA imaging of hepatocellular carcinoma (HCC). Our prospective study evaluates the role of <sup>68</sup>Ga-PSMA in HCC patients and compares it to conventional imaging (CE-CT/MRI).</p><p><strong>Methods: </strong>Patients with radiologically and/or histopathologically confirmed HCC were included and all had undergone serum alpha-fetoprotein (S.AFP) assessment as well as CE-CT/MRI prior to PSMA PET/CT. Acquired whole-body PET/CTs were analysed both visually and quantitatively by two experienced nuclear medicine physicians.</p><p><strong>Results: </strong>Forty-one (41) patients (36 male; 5 female) with known HCC and a mean age of 53.9 ± 10.9 years underwent <sup>68</sup>Ga-PSMA PET/CT. All patients had lesions on conventional imaging but only 38/41 patients showed <sup>68</sup>Ga-PSMA uptake. Conventional imaging revealed 18 patients with single lesions, all of which were tracer avid. Twenty-three (23) of 41 patients had multifocal (> 2) hepatic lesions on CE-CT/MRI of which 3 patients showed no <sup>68</sup>Ga-PSMA uptake, 7 showed tracer uptake in a single lesion only and 13 patients had multifocal tracer avid lesions. There was no correlation observed between S. AFP level and tumour SUV<sub>max</sub> on <sup>68</sup>Ga-PSMA PET/CT.</p><p><strong>Conclusion: </strong><sup>68</sup>Ga-PSMA PET/CT imaging of HCC may complement conventional imaging and identify patients for potential theranostic intervention.</p>\",\"PeriodicalId\":8007,\"journal\":{\"name\":\"Annals of Nuclear Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12149-023-01876-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/11/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12149-023-01876-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
A prospective study of 68Ga-PSMA PET/CT imaging of HCC as diagnosed on conventional imaging to evaluate for potential 177Lu-PSMA therapy.
Objective: PSMA expression is seen in many solid tumours in addition to prostate cancer and several studies and case reports have shown PSMA expression and 68Ga-PSMA imaging of hepatocellular carcinoma (HCC). Our prospective study evaluates the role of 68Ga-PSMA in HCC patients and compares it to conventional imaging (CE-CT/MRI).
Methods: Patients with radiologically and/or histopathologically confirmed HCC were included and all had undergone serum alpha-fetoprotein (S.AFP) assessment as well as CE-CT/MRI prior to PSMA PET/CT. Acquired whole-body PET/CTs were analysed both visually and quantitatively by two experienced nuclear medicine physicians.
Results: Forty-one (41) patients (36 male; 5 female) with known HCC and a mean age of 53.9 ± 10.9 years underwent 68Ga-PSMA PET/CT. All patients had lesions on conventional imaging but only 38/41 patients showed 68Ga-PSMA uptake. Conventional imaging revealed 18 patients with single lesions, all of which were tracer avid. Twenty-three (23) of 41 patients had multifocal (> 2) hepatic lesions on CE-CT/MRI of which 3 patients showed no 68Ga-PSMA uptake, 7 showed tracer uptake in a single lesion only and 13 patients had multifocal tracer avid lesions. There was no correlation observed between S. AFP level and tumour SUVmax on 68Ga-PSMA PET/CT.
Conclusion: 68Ga-PSMA PET/CT imaging of HCC may complement conventional imaging and identify patients for potential theranostic intervention.
期刊介绍：
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
