Wenlei Zhang, Jiahui Zhou, Hang Su, Xiaocheng Zhang, Weichen Song, Zijing Wang, Chengjie Tang, Kadir Uludağ, Min Zhao, Zhi-Qi Xiong, Rongwei Zhai, Haifeng Jiang
{"title":"反复接触甲基苯丙胺可降低恒河猴血浆脑源性神经营养因子水平。","authors":"Wenlei Zhang, Jiahui Zhou, Hang Su, Xiaocheng Zhang, Weichen Song, Zijing Wang, Chengjie Tang, Kadir Uludağ, Min Zhao, Zhi-Qi Xiong, Rongwei Zhai, Haifeng Jiang","doi":"10.1136/gpsych-2023-101127","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Brain-derived neurotrophic factor (BDNF) is known to prevent methamphetamine (METH)-induced neurotoxicity and plays a role in various stages of METH addiction. However, there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals.</p><p><strong>Aims: </strong>The aim of the study was to investigate changes in BDNF levels during METH self-administration in monkeys.</p><p><strong>Methods: </strong>This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure. Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self-administration in the three monkeys.</p><p><strong>Results: </strong>Repeated METH exposure decreased plasma BDNF levels. Additionally, plasma BDNF decreased with long-term rather than short-term accumulation of METH during METH self-administration.</p><p><strong>Conclusions: </strong>These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period.</p>","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618972/pdf/","citationCount":"0","resultStr":"{\"title\":\"Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys.\",\"authors\":\"Wenlei Zhang, Jiahui Zhou, Hang Su, Xiaocheng Zhang, Weichen Song, Zijing Wang, Chengjie Tang, Kadir Uludağ, Min Zhao, Zhi-Qi Xiong, Rongwei Zhai, Haifeng Jiang\",\"doi\":\"10.1136/gpsych-2023-101127\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Brain-derived neurotrophic factor (BDNF) is known to prevent methamphetamine (METH)-induced neurotoxicity and plays a role in various stages of METH addiction. However, there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals.</p><p><strong>Aims: </strong>The aim of the study was to investigate changes in BDNF levels during METH self-administration in monkeys.</p><p><strong>Methods: </strong>This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure. Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self-administration in the three monkeys.</p><p><strong>Results: </strong>Repeated METH exposure decreased plasma BDNF levels. Additionally, plasma BDNF decreased with long-term rather than short-term accumulation of METH during METH self-administration.</p><p><strong>Conclusions: </strong>These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period.</p>\",\"PeriodicalId\":12549,\"journal\":{\"name\":\"General Psychiatry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2023-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618972/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"General Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/gpsych-2023-101127\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"General Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/gpsych-2023-101127","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Background: Brain-derived neurotrophic factor (BDNF) is known to prevent methamphetamine (METH)-induced neurotoxicity and plays a role in various stages of METH addiction. However, there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals.
Aims: The aim of the study was to investigate changes in BDNF levels during METH self-administration in monkeys.
Methods: This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure. Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self-administration in the three monkeys.
Results: Repeated METH exposure decreased plasma BDNF levels. Additionally, plasma BDNF decreased with long-term rather than short-term accumulation of METH during METH self-administration.
Conclusions: These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period.
期刊介绍：
General Psychiatry (GPSYCH), an open-access journal established in 1959, has been a pioneer in disseminating leading psychiatry research. Addressing a global audience of psychiatrists and mental health professionals, the journal covers diverse topics and publishes original research, systematic reviews, meta-analyses, forums on topical issues, case reports, research methods in psychiatry, and a distinctive section on 'Biostatistics in Psychiatry'. The scope includes original articles on basic research, clinical research, community-based studies, and ecological studies, encompassing a broad spectrum of psychiatric interests.
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