体外光合疗法在肾移植中的免疫调节:概念验证的临床结果和前景

Thomas Crépin, Arnaud Lionet, Jean-François Augusto, Marc Hazzan, Cyril Garrouste, Anne-Elisabeth Heng, Didier Ducloux
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引用次数: 0

摘要

30年来,光疗法一直被用于治疗移植物抗宿主疾病和心脏或肺移植物排斥反应。在这篇综述中,我们讨论了光刺激在肾移植中预防或治疗排斥反应的作用。肾移植的作用机制主要基于在移植物抗宿主疾病和心脏或肺移植中观察到的结果。光切可以诱导先天和适应性免疫变化,恢复有利的Th1/Th2免疫平衡,扩大LT/LB-reg亚群,并局部富集IL-10。法国国家临床和机制研究正在进行中,以确定光疗法在肾移植免疫调节策略中的地位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Immune modulation with extracorporeal photopheresis in renal transplantation: proof of concept clinical outcomes and perspective].

For 30 years, photopheresis is used to treat graft versus host disease and heart or lung allograft rejection. In this review, we discuss the place of photopheresis in kidney transplantation both in prevention or treatment of rejection. Mechanisms of action in kidney transplantation are mainly based on results observed in graft versus host disease and in heart or lung transplantation. Photopheresis may induce innate and adaptive immunity changes with restauration of a favourable Th1/Th2 immune balance, an expansion of LT /LB reg subsets, and a local enrichment in IL-10. French national clinical and mechanistic studies are underway to define the place of photopheresis therapy in immunomodulation strategies in kidney transplantation.

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