类风湿性关节炎患者的促炎细胞因子与焦虑和抑郁症状之间的关系：一项横断面研究。

Q2 Medicine

Clinical Practice and Epidemiology in Mental Health Pub Date : 2023-06-22 eCollection Date: 2023-01-01 DOI:10.2174/17450179-v19-e230510-2022-34

Faisal Parlindungan, Rudy Hidayat, Anna Ariane, Hamzah Shatri

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引用次数: 0

摘要

背景：类风湿性关节炎（RA）患者焦虑和抑郁的患病率较高。RA患者的炎性细胞因子升高。我们的目的是评估RA的全身炎症与焦虑和抑郁之间的关系。方法：RA患者31例，活动期16例，缓解期15例；他们使用医院焦虑和抑郁量表进行评估，并使用28关节疾病活动评分（DAS28）-CRP（C反应蛋白）进行RA疾病活动评估。结果：31例患者中，10例出现焦虑症状，19例出现抑郁症状，2例出现混合症状。活动性疾病患者血清TNF-α水平显著高于缓解组（p值0.006）。活动性疾病组和缓解组的促炎细胞因子与焦虑和抑郁症状之间没有关联或相关性。结论：RA患者除疾病活动和全身炎症状态外，还可能存在其他因素引起焦虑和抑郁。

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Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms in Rheumatoid Arthritis Patients: A Cross-sectional Study.

Background: Rheumatoid arthritis (RA) patients have a greater prevalence of anxiety and depression. Proinflammatory cytokines are elevated in RA. We aim to evaluate the association between systemic inflammation in RA and anxiety and depression.

Methods: There were 31 RA patients, 16 with active disease activity and 15 in remission state; they were assessed using the Hospital Anxiety and Depression Scale and for RA disease activity using Disease Activity Score of 28 joints (DAS28) - CRP (C-reactive protein). Serum proinflammatory cytokines were measured, including interleukin (IL)-6, IL-17, and Tumour Necrosis Factor-alpha (TNF-α).

Results: Among 31 patients, ten patients showed anxiety symptoms, 19 patients showed depression symptoms, and two displayed mixed symptoms. Serum TNF-α levels were significantly higher in active disease than in the remission group (p-value 0.006). There was no association or correlation between proinflammatory cytokines to anxiety and depression symptoms in the active disease and remission groups.

Conclusion: This suggests that other factors besides disease activity and state of systemic inflammation may cause anxiety and depression in RA patients.

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来源期刊

Clinical Practice and Epidemiology in Mental Health Medicine-Psychiatry and Mental Health

CiteScore

5.30

自引率

0.00%

发文量

期刊介绍： Clinical Practice & Epidemiology in Mental Health is an open access online journal, which publishes Research articles, Reviews, Letters in all areas of clinical practice and epidemiology in mental health covering the following topics: Clinical and epidemiological research in psychiatry and mental health; diagnosis, prognosis and treatment of mental health conditions; and frequencies and determinants of mental health conditions in the community and the populations at risk; research and economic aspects of psychiatry, with special attention given to manuscripts presenting new results and methods in the area; and clinical epidemiologic investigation of pharmaceutical agents. Clinical Practice & Epidemiology in Mental Health, a peer reviewed journal, aims to provide the most complete and reliable source of information on current developments in the field. The emphasis will be on publishing quality articles rapidly and freely available worldwide.