T1w/T2w标测技术在退行性颈脊髓病患者脊髓评估中的应用。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Spinal cord Pub Date : 2023-11-02 DOI:10.1038/s41393-023-00941-y

Elena Filimonova, Vladimir Letyagin, Boris Zaitsev, Yulij Kubetsky, Jamil Rzaev

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引用次数: 0

摘要

研究设计：回顾性病例对照研究。目的：研究退行性脊髓型颈椎病（DCM）患者颈髓内T1w/T2w信号强度比图的信号变化。地点：俄罗斯新西伯利亚神经外科中心。方法：采用T1w/T2w标测法和脊髓自动形态测量法对261名DCM患者和42名年龄和性别匹配的健康对照进行评估。计算反映白质完整性的T1w/T2w信号强度比和脊髓截面积（CSA），并在患者和对照组之间进行比较。在DCM患者中，还评估了这些参数与神经评分之间的相关性。结果：扩张型心肌病患者在最大压迫水平下颈脊髓的区域T1w/T2w比值显著低于健康对照组（p 结论：根据自动形态计量学，T1w/T2w标测显示DCM伴脊髓萎缩患者的脊髓组织损伤存在于最大压迫水平。这些变化是相互关联的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Application of the T1w/T2w mapping technique for spinal cord assessment in patients with degenerative cervical myelopathy

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Application of the T1w/T2w mapping technique for spinal cord assessment in patients with degenerative cervical myelopathy

Retrospective case-control study. To investigate signal changes on T1w/T2w signal intensity ratio maps within cervical cord in patients with degenerative cervical myelopathy (DCM). Novosibirsk Neurosurgery Center, Russia. A total of 261 patients with DCM and 42 age- and sex-matched healthy controls were evaluated using the T1w/T2w mapping method and spinal cord automatic morphometry. The T1w/T2w signal intensity ratio, which reflects white matter integrity, and the spinal cord cross-sectional area (CSA) were calculated and compared between the patients and the controls. In patients with DCM, the correlations between these parameters and neurological scores were also evaluated. The regional T1w/T2w ratio values from the cervical spinal cord at the level of maximal compression in patients with DCM were significantly lower than those in healthy controls (p < 0.001), as were the regional CSA values (p < 0.001). There was a positive correlation between the regional values of the T1w/T2w ratio and the values of the CSA at the level of maximal spinal cord compression. T1w/T2w mapping revealed that spinal cord tissue damage exists at the level of maximal compression in patients with DCM in association with spinal cord atrophy according to automatic morphometry. These changes were correlated with each other.

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来源期刊

Spinal cord 医学-临床神经学

CiteScore

4.50

自引率

9.10%

发文量

142

审稿时长

2 months

期刊介绍： Spinal Cord is a specialised, international journal that has been publishing spinal cord related manuscripts since 1963. It appears monthly, online and in print, and accepts contributions on spinal cord anatomy, physiology, management of injury and disease, and the quality of life and life circumstances of people with a spinal cord injury. Spinal Cord is multi-disciplinary and publishes contributions across the entire spectrum of research ranging from basic science to applied clinical research. It focuses on high quality original research, systematic reviews and narrative reviews. Spinal Cord''s sister journal Spinal Cord Series and Cases: Clinical Management in Spinal Cord Disorders publishes high quality case reports, small case series, pilot and retrospective studies perspectives, Pulse survey articles, Point-couterpoint articles, correspondences and book reviews. It specialises in material that addresses all aspects of life for persons with spinal cord injuries or disorders. For more information, please see the aims and scope of Spinal Cord Series and Cases.