牙髓炎症性疾病的加权综合征与首次心肌梗死有关。

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Oral health & preventive dentistry Pub Date : 2023-11-02 DOI:10.3290/j.ohpd.b4586815

Dan Sebring, Nils-Gunnar Pehrsson, Kåre Buhlin, Peter Jonasson, Henrik Lund, Thomas Kvist

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引用次数: 0

摘要

目的：探讨根管炎性疾病（EID）作为首次心肌梗死（MI）危险因素的加权复合物。材料和方法：对797名首次心肌梗死患者和796名对照组的7种与EID相关的牙齿特异性疾病进行了放射学评估。EID的加权组合计算为所有牙齿的总和，不包括第三磨牙。使用最大似然估计，为每个条件分配一个特定的权重。通过多变量条件回归，EID变量、牙周病和缺牙被评估为首次MI的预测因素。结果：牙周病（OR 1.38；95%CI 1.13-1.69，p=0.0016）和缺牙（OR 1.03；95%CI 1.002-1.05，p=0.034）与首次MI的风险相关，而没有一种与EID相关的情况单独相关。然而，当作为一个集合进行评估时，EID（OR 1.97；95%CI 1.23-31.17，p=0.0050）和牙周病（OR 1.34；95%CI 1.09-1.63，p=0.0046）的加权组合与MI的风险相关。在最终模型中，缺失牙齿并不是MI的统计学显著预测因素。结论：EID的加权复合物与MI的风险相关，并加强了口腔炎症疾病和心血管疾病之间直接联系的证据。

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A Weighted Composite of Endodontic Inflammatory Disease is Linked to a First Myocardial Infarction.

Purpose: To explore a weighted composite of endodontic inflammatory disease (EID) as a risk factor for suffering a first myocardial infarction (MI).

Materials and methods: Seven tooth-specific conditions related to EID were assessed radiographically in 797 patients suffering a first MI and 796 controls. A weighted composite of EID was calculated as the sum of all teeth, excluding third molars. Using maximum likelihood estimation, each condition was assigned a specific weight. With multivariable conditional regression, EID variables, periodontal disease, and missing teeth were assessed as predictors of a first MI.

Results: Periodontal disease (OR 1.38; 95% CI 1.13-1.69, p = 0.0016) and missing teeth (OR 1.03; 95% CI 1.002-1.05, p = 0.034) were related to the risk of a first MI, while none of the EID-related conditions individually were. However, when assessed as an aggregate, a weighted composite of EID (OR 1.97; 95% CI 1.23-3.17, p = 0.0050) and periodontal disease (OR 1.34; 95% CI 1.09-1.63, p = 0.0046) was associated with the risk of MI. Missing teeth did not remain a statistically significant predictor of MI in the final model.

Conclusions: A weighted composite of EID was associated with the risk of MI and strengthens the evidence for a direct connection between oral inflammatory diseases and cardiovascular disorders.

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来源期刊

Oral health & preventive dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinicians, general practitioners, teachers, researchers, and public health administrators will find this journal an indispensable source of essential, timely information about scientific progress in the fields of oral health and the prevention of caries, periodontal diseases, oral mucosal diseases, and dental trauma. Central topics, including oral hygiene, oral epidemiology, oral health promotion, and public health issues, are covered in peer-reviewed articles such as clinical and basic science research reports; reviews; invited focus articles, commentaries, and guest editorials; and symposium, workshop, and conference proceedings.