母体补充甲基供体可以调节自助餐厅饮食对雄性后代行为变化和营养状况的影响。

IF 3.5 4区 医学 Q2 FOOD SCIENCE & TECHNOLOGY
Food & Nutrition Research Pub Date : 2023-10-27 eCollection Date: 2023-01-01 DOI:10.29219/fnr.v67.9828
Katya Herrera, Roger Maldonado-Ruiz, Alberto Camacho-Morales, Ana Laura de la Garza, Heriberto Castro
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引用次数: 0

摘要

背景:围产期和产后的营养状况和母亲的喂养可以使后代产生长期的健康变化。流行病学研究表明,母亲肥胖与后代的智力残疾/认知缺陷(如自闭症谱系障碍)之间存在关联。实验结果一致表明,母体补充甲基供体可以减轻后代的社会变化和重复行为。目的:本研究旨在分析母亲自助餐厅饮食和甲基供体补充饮食对雄性后代社交、焦虑和重复行为的影响,同时评估母鼠和雄性后代的体重增加和食物摄入。设计:C57BL/6雌性小鼠在孕前、妊娠期和哺乳期被随机分为四种膳食配方:对照周(CT)、自助餐厅(CAF)、对照+甲基供体(CT+M)和自助餐厅+甲基供体。2个月大的孩子使用三腔试验、开放式田间试验和大理石埋葬试验对后代进行了行为表型分析。结果:我们发现,与Chow饮食的受试者(CT组)相比,产前接触CAF饮食的后代表现出较少的社会互动指数。值得注意的是,与CAF组相比,暴露于CAF+M饮食的后代恢复了社会互动。讨论:这些发现表明,母体CAF饮食在促进小鼠模型中减少社会互动方面是有效的。在我们的研究中,我们假设补充母体甲基供体可以改善母体CAF饮食后代的行为变化。结论:CAF饮食也导致了后代的社交缺陷和焦虑样行为。另一方面,母亲补充甲基供体的CAF饮食使后代的社会互动正常化,尽管这会导致焦虑样行为的增加。这些发现表明,补充甲基供体可以防止可能针对与神经递质途径相关的关键基因的异常社会行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Maternal methyl donor supplementation regulates the effects of cafeteria diet on behavioral changes and nutritional status in male offspring.

Maternal methyl donor supplementation regulates the effects of cafeteria diet on behavioral changes and nutritional status in male offspring.

Maternal methyl donor supplementation regulates the effects of cafeteria diet on behavioral changes and nutritional status in male offspring.

Maternal methyl donor supplementation regulates the effects of cafeteria diet on behavioral changes and nutritional status in male offspring.

Background: Nutritional status and maternal feeding during the perinatal and postnatal periods can program the offspring to develop long-term health alterations. Epidemiologic studies have demonstrated an association between maternal obesity and intellectual disability/cognitive deficits like autism spectrum disorders (ASDs) in offspring. Experimental findings have consistently been indicating that maternal supplementation with methyl donors, attenuated the social alterations and repetitive behavior in offspring.

Objective: This study aims to analyze the effect of maternal cafeteria diet and methyl donor-supplemented diets on social, anxiety-like, and repetitive behavior in male offspring, besides evaluating weight gain and food intake in both dams and male offspring.

Design: C57BL/6 female mice were randomized into four dietary formulas: control Chow (CT), cafeteria (CAF), control + methyl donor (CT+M), and cafeteria + methyl donor (CAF+M) during the pre-gestational, gestational, and lactation period. Behavioral phenotyping in the offspring was performed by 2-month-old using Three-Chamber Test, Open Field Test, and Marble Burying Test.

Results: We found that offspring prenatally exposed to CAF diet displayed less social interaction index when compared with subjects exposed to Chow diet (CT group). Notably, offspring exposed to CAF+M diet recovered social interaction when compared to the CAF group.

Discussion: These findings suggest that maternal CAF diet is efficient in promoting reduced social interaction in murine models. In our study, we hypothesized that a maternal methyl donor supplementation could improve the behavioral alterations expected in maternal CAF diet offspring.

Conclusions: The CAF diet also contributed to a social deficit and anxiety-like behavior in the offspring. On the other hand, a maternal methyl donor-supplemented CAF diet normalized the social interaction in the offspring although it led to an increase in anxiety-like behaviors. These findings suggest that a methyl donor supplementation could protect against aberrant social behavior probably targeting key genes related to neurotransmitter pathways.

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来源期刊
Food & Nutrition Research
Food & Nutrition Research FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS
CiteScore
5.20
自引率
9.10%
发文量
47
审稿时长
14 weeks
期刊介绍: Food & Nutrition Research is a peer-reviewed journal that presents the latest scientific research in various fields focusing on human nutrition. The journal publishes both quantitative and qualitative research papers. Through an Open Access publishing model, Food & Nutrition Research opens an important forum for researchers from academic and private arenas to exchange the latest results from research on human nutrition in a broad sense, both original papers and reviews, including: * Associations and effects of foods and nutrients on health * Dietary patterns and health * Molecular nutrition * Health claims on foods * Nutrition and cognitive functions * Nutritional effects of food composition and processing * Nutrition in developing countries * Animal and in vitro models with clear relevance for human nutrition * Nutrition and the Environment * Food and Nutrition Education * Nutrition and Economics Research papers on food chemistry (focus on chemical composition and analysis of foods) are generally not considered eligible, unless the results have a clear impact on human nutrition. The journal focuses on the different aspects of nutrition for people involved in nutrition research such as Dentists, Dieticians, Medical doctors, Nutritionists, Teachers, Journalists and Manufacturers in the food and pharmaceutical industries.
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