γ-谷氨酰转肽酶和间接胆红素可能参与银屑病关节炎患者的全身炎症。

IF 2 4区 医学 Q3 RHEUMATOLOGY
Xu Wang, Yan Mao, Shang Ji, Huanrong Hu, Qian Li, Lichao Liu, Shaomin Shi, Yaling Liu
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引用次数: 0

摘要

背景:先前的研究表明,系统代谢异常与银屑病关节炎(PsA)密切相关。γ-谷氨酰转肽酶(GGT)和间接胆红素(IBIL)是肝脏代谢中的两种重要活性物质,分别被证明是一种氧化因子和抗氧化因子,已被证明与几种人类疾病的氧化应激损伤和炎症有关。然而,他们在PsA中的作用尚不清楚。方法:在本回顾性比较队列研究中,河北医科大学第三医院的68名PsA患者和73名健康志愿者作为对照组。比较两组患者血清GGT、IBIL、GGT/IBIL比值和C反应蛋白(CRP),这是一种应用广泛的PsA全身炎症的生物标志物。此外,还探讨了银屑病患者GGT、IBIL和GGT/IBIL与CRP的关系。最后,根据CRP中位值将患者分为高炎症组和低炎症组。采用多变量逻辑回归分析全身炎症水平与GGT、IBIL和GGT/IBIL的关系。结果:与健康对照组相比,PsA患者的血清GGT、GGT/IBIL和CRP水平显著升高,IBIL水平较低。血清GGT和GGT/IBIL与CRP呈正相关,而IBIL则与CRP呈负相关。二元逻辑回归分析显示,血清GGT是PsA高CRP的危险因素,而IBIL是一个保护因素。此外,根据受试者的操作特征曲线,GGT/IBIL比单独的GGT或IBIL更好地指示PsA患者的高CRP状况。结论:GGT和IBIL可能参与了PsA的发病机制。此外,GGT、IBIL和两者的平衡可能在一定程度上反映了与代谢异常相关的氧化应激事件介导的全身炎症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gamma-glutamyl transpeptidase and indirect bilirubin may participate in systemic inflammation of patients with psoriatic arthritis.

Background: Previous studies have suggested that systemic metabolic abnormalities are closely related to psoriatic arthritis (PsA). Gamma-glutamyl transpeptidase (GGT) and indirect bilirubin (IBIL), two essential active substances in hepatic metabolism that have been demonstrated as an oxidative and anti-oxidative factor respectively, have been proved to be involved in oxidative stress damage and inflammation in several human diseases. However, their role in PsA remains unclear.

Methods: In this retrospective comparative cohort study, a case group of 68 PsA patients and a control group of 73 healthy volunteers from the Third Hospital of Hebei Medical University were enrolled. Serum GGT, IBIL, GGT/IBIL ratio and C-reactive protein (CRP), a well applied bio-marker of systemic inflammatory in PsA, were compared between the two groups. Furthermore, the relationship of GGT, IBIL and GGT/IBIL with CRP were explored in PsA patients. Finally, the patients were divided into high inflammation group and low inflammation group according to the median value of CRP. Multivariate logistic regression analyses were used for the association of systemic inflammation level with GGT, IBIL and GGT/IBIL.

Results: Compared with healthy controls, PsA patients exhibited significantly higher serum GGT, GGT/IBIL, and CRP levels and lower IBIL levels. Serum GGT and GGT/IBIL were positively correlated with CRP, whereas IBIL were negatively correlated with CRP. Binary logistic regression analysis revealed that serum GGT was a risk factor for high CRP in PsA, whereas IBIL was a protective factor. Furthermore, GGT/IBIL was a better indicator of high CRP condition in PsA patients than either GGT or IBIL alone, as determined by the receiver operating characteristic curves.

Conclusion: GGT and IBIL may participate in the pathogenesis of PsA. Additionally, GGT, IBIL and the balance of the two may reflect systemic inflammation mediated by oxidative stress events related to metabolic abnormalities to a certain extent.

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来源期刊
Advances in Rheumatology
Advances in Rheumatology Medicine-Rheumatology
CiteScore
4.00
自引率
4.30%
发文量
41
审稿时长
53 weeks
期刊介绍: Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.
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