用于药物化合物分析的环境样品稳定性:处理和保存建议。

IF 2.3 3区 化学 Q3 CHEMISTRY, ANALYTICAL
Journal of Analytical Methods in Chemistry Pub Date : 2023-10-19 eCollection Date: 2023-01-01 DOI:10.1155/2023/5526429
Nuning Vita Hidayati, Laurence Asia, Stephanie Lebarillier, Ita Widowati, Agus Sabdono, Anne Piram, Rizqi Rizaldi Hidayat, Dina Fitriyah, Indra Putra Almanar, Pierre Doumenq, Agung Dhamar Syakti
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引用次数: 0

摘要

用于处理样品的高效和有弹性的技术对于检测环境中的药物化合物是必不可少的。本研究探索了一种在定量分析之前在运输过程中保存水样的方法。本研究考察了17α-乙炔基雌二醇(EE2)、对乙酰氨基酚(ACM)、土霉素(OTC)、磺胺甲恶唑(SMX)和甲氧苄啶(TMP)在固相萃取(SPE)筒内预浓缩后的稳定性。通过涉及不同保温时间和储存温度的各种实验,确定了四种药物化合物在4°C下储存一个月和在-18°C下黑暗储存六个月时保持稳定。将这些化合物储存在-18°C的SPE筒中似乎可以有效地长期保存。此外,ACM、TMP、OTC、EE2和SMX在室温下保持稳定三天。这些发现为使用SPE从水性环境样品中预浓缩的药物化合物的适当储存和处理实践建立了指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations.

Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations.

Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations.

Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations.

Efficient and resilient techniques for handling samples are essential for detecting pharmaceutical compounds in the environment. This study explores a method for preserving water samples during transport before quantitative analysis. The study investigates the stability of 17α-ethynylestradiol (EE2), acetaminophen (ACM), oxytetracycline (OTC), sulfamethoxazole (SMX), and trimethoprim (TMP) after preconcentration within solid-phase extraction (SPE) cartridges. Through various experiments involving different holding times and storage temperatures, it was determined that four pharmaceutical compounds remained stable when stored for a month at 4°C and for six months when stored at -18°C in darkness. Storing these compounds in SPE cartridges at -18°C seemed effective in preserving them for extended periods. In addition, ACM, TMP, OTC, EE2, and SMX remained stable for three days at room temperature. These findings establish guidelines for appropriate storage and handling practices of pharmaceutical compounds preconcentrated from aqueous environmental samples using SPE.

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来源期刊
Journal of Analytical Methods in Chemistry
Journal of Analytical Methods in Chemistry CHEMISTRY, ANALYTICAL-ENGINEERING, CIVIL
CiteScore
4.80
自引率
3.80%
发文量
79
审稿时长
6-12 weeks
期刊介绍: Journal of Analytical Methods in Chemistry publishes papers reporting methods and instrumentation for chemical analysis, and their application to real-world problems. Articles may be either practical or theoretical. Subject areas include (but are by no means limited to): Separation Spectroscopy Mass spectrometry Chromatography Analytical Sample Preparation Electrochemical analysis Hyphenated techniques Data processing As well as original research, Journal of Analytical Methods in Chemistry also publishes focused review articles that examine the state of the art, identify emerging trends, and suggest future directions for developing fields.
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