新型复合牙胶的抗菌性能。

Q3 Pharmacology, Toxicology and Pharmaceutics

Ceska a Slovenska Farmacie Pub Date : 2023-01-01 DOI:10.5817/csf2023-2-95

Nataliia Dev Atkina

{"title":"新型复合牙胶的抗菌性能。","authors":"Nataliia Dev Atkina","doi":"10.5817/csf2023-2-95","DOIUrl":null,"url":null,"abstract":"Given the role of the microbial factor in the development of infectious-inflammatory processes in the oral mucosa, the research aim was to study the antimicrobial action of a new combined dental gel containing Rotocan® (10%) and triclosan (0.4%) in vitro and in the traumatic stomatitis in albino rats. Rotrin- Denta® exhibited strong antimicrobial activity against etalon strains of gram-positive (S. aureus ATTC 6538, S. pyogenes DICK 1, B. subtilis ATCC 6633) and gramnegative (E. coli ATCC 25922) bacteria, which exceeded the action of the reference drug Camident-Zdorovia® and weak effects on pseudomonads (P. aeruginosa ATCC 27853) and fungi (C. albicans CCV 885-653), which is less to the reference preparation. Rotrin- Denta® reduced microbial insemination and eliminated oral dysbiosis in albino rats with traumatic stomatitis, exceeding the effect of Kamident-Zdorov'ya®. The results open up the prospect of its clinical testing and further implementation in the dentistry practice.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"72 2 1","pages":"95-99"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial properties of the new combined dental gel.\",\"authors\":\"Nataliia Dev Atkina\",\"doi\":\"10.5817/csf2023-2-95\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Given the role of the microbial factor in the development of infectious-inflammatory processes in the oral mucosa, the research aim was to study the antimicrobial action of a new combined dental gel containing Rotocan® (10%) and triclosan (0.4%) in vitro and in the traumatic stomatitis in albino rats. Rotrin- Denta® exhibited strong antimicrobial activity against etalon strains of gram-positive (S. aureus ATTC 6538, S. pyogenes DICK 1, B. subtilis ATCC 6633) and gramnegative (E. coli ATCC 25922) bacteria, which exceeded the action of the reference drug Camident-Zdorovia® and weak effects on pseudomonads (P. aeruginosa ATCC 27853) and fungi (C. albicans CCV 885-653), which is less to the reference preparation. Rotrin- Denta® reduced microbial insemination and eliminated oral dysbiosis in albino rats with traumatic stomatitis, exceeding the effect of Kamident-Zdorov'ya®. The results open up the prospect of its clinical testing and further implementation in the dentistry practice.\",\"PeriodicalId\":38771,\"journal\":{\"name\":\"Ceska a Slovenska Farmacie\",\"volume\":\"72 2 1\",\"pages\":\"95-99\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ceska a Slovenska Farmacie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5817/csf2023-2-95\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ceska a Slovenska Farmacie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5817/csf2023-2-95","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

摘要

考虑到微生物因素在口腔黏膜感染-炎症过程中的作用，本研究的目的是研究一种含有Rotocan®(10%)和三氯生(0.4%)的新型联合牙凝胶在体外和在白化大鼠创伤性口炎中的抗菌作用。Rotrin- Denta®对革兰氏阳性菌(金黄色葡萄球菌ATTC 6538、化脓葡萄球菌DICK 1、枯草芽孢杆菌ATCC 6633)和革兰氏阴性菌(大肠杆菌ATCC 25922)的抑菌活性较强，超过参比药Camident-Zdorovia®，对假单胞菌(铜绿假单胞菌ATCC 27853)和真菌(白色念珠菌CCV 885-653)的抑菌作用较弱，低于参比药。Rotrin- Denta®减少了白化大鼠创伤性口炎的微生物受精和消除了口腔生态失调，超过了Kamident-Zdorov'ya®的效果。研究结果为其临床试验及在牙科实践中的进一步应用开辟了前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Antimicrobial properties of the new combined dental gel.

Given the role of the microbial factor in the development of infectious-inflammatory processes in the oral mucosa, the research aim was to study the antimicrobial action of a new combined dental gel containing Rotocan® (10%) and triclosan (0.4%) in vitro and in the traumatic stomatitis in albino rats. Rotrin- Denta® exhibited strong antimicrobial activity against etalon strains of gram-positive (S. aureus ATTC 6538, S. pyogenes DICK 1, B. subtilis ATCC 6633) and gramnegative (E. coli ATCC 25922) bacteria, which exceeded the action of the reference drug Camident-Zdorovia® and weak effects on pseudomonads (P. aeruginosa ATCC 27853) and fungi (C. albicans CCV 885-653), which is less to the reference preparation. Rotrin- Denta® reduced microbial insemination and eliminated oral dysbiosis in albino rats with traumatic stomatitis, exceeding the effect of Kamident-Zdorov'ya®. The results open up the prospect of its clinical testing and further implementation in the dentistry practice.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Ceska a Slovenska Farmacie Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Přehledový článek je zaměřen zejména na metody přípravy, charakterizaci mikročástic a dále na charakteristiku a příklady jejich možného využití ve farmakoterapii. Mikročástice jako...