S. Bilgin, G. Aktas, Tel Atak, O. Kurtkulagi, G. Kahveci, T. Duman, Havva Akın, Buse Balci, Asli Erturk
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引用次数: 10
摘要
简介/目的:微血管和大血管并发症导致2型糖尿病(T2DM)过程中反复住院、住院、残疾和死亡。甘油三酯与高密度脂蛋白胆固醇比值(THR)与胰岛素抵抗有关。我们旨在了解T2DM患者THR与糖尿病并发症之间是否存在关系。方法:T2DM患者入组研究。研究人群根据有无糖尿病并发症分为两组。比较糖尿病合并组(A组)和非糖尿病合并组(B组)的特点和实验室资料。结果:A、B组THR中位数分别为3.86(0.33 ~ 53.38)、2.86(0.63 ~ 17.88),差异有统计学意义(p = 0.006)。THR水平与糖化血红蛋白(HbA1c) (r = 0.12, p = 0.04)和空腹血糖水平(r = 0.14, p = 0.02)呈显著正相关。结论:2型糖尿病患者应监测THR,以便及早发现糖尿病微血管并发症。THR水平升高应促使对这一人群的糖尿病并发症进行进一步调查。
Triglyceride to high density lipoprotein cholesterol ratio is elevated in patients with complicated type 2 diabetes mellitus
Introduction/Aims: Microvascular and macrovascular complications lead to recurrent hospital admissions, hospitalizations, disability, and death in the course of type 2 diabetes mellitus (T2DM). Triglyceride to HDL cholesterol ratio (THR) is associated with insulin resistance. We aimed to find out whether there is a relationship between THR and diabetic complications in patients with T2DM. Methods: Patients with T2DM were enrolled in the study. The study population was divided into two groups according to the presence or absence of diabetic complications. Characteristics and laboratory data of the patients with (group A) and without (group B) diabetic complications were compared. Results: Median THR values of the groups A and B were 3.86 (0.33-53.38) and 2.86 (0.63-17.88), respectively (p = 0.006). THR level was significantly and positively correlated with glycated hemoglobin (HbA1c) (r = 0.12, p = 0.04) and fasting glucose levels (r = 0.14, p = 0.02). Conclusion: We suggest that THR should be monitored in patients with type 2 diabetes mellitus in order to detect diabetic microvascular complications earlier. Increased THR levels should prompt further investigation of diabetic complications in this population.