颈动脉内膜切除术后再狭窄的发生率

Bojana Arnautović, I. Končar
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引用次数: 0

摘要

颈动脉再狭窄是颈动脉内膜切除术后一个重要的长期并发症。颈动脉再狭窄是术后早期新生内膜增生或术后复发的动脉粥样硬化病变的结果。许多研究表明,几种危险因素是再狭窄的易感条件。然而,每个诱发因素的确切作用仍然存在广泛的争论。目的:探讨颈动脉内膜切除术后再狭窄的发生频率及危险因素。材料和方法:回顾了2008年至2010年间295例颈动脉内膜切除术患者的资料。在2011年至2019年期间对对照检查进行术后双工研究。回顾性分析患者的人口学、临床和实验室特征对颈动脉内膜切除术后再狭窄发生的影响。结果:颈动脉内膜切除术后发生再狭窄76例(26%),其中随访第3年(33%)和第4年(25%)发生率最高。糖尿病患者(p = 0.048)和外周动脉闭塞疾病患者(p = 0.041)与再狭窄的发生、血脂状态参数-胆固醇值(p = 0.025)、血清低密度脂蛋白(p = 0.036)和非高密度脂蛋白(p = 0.041)均有显著的统计学相关性。结论:我们的研究结果证实了动脉粥样硬化危险因素在术后后期颈动脉再狭窄发生中的重要作用。为了防止颈动脉再狭窄的发展,有必要更频繁地监测和控制这些患者的全身危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Frequency of restenosis after carotid endarterectomy
Introduction: Carotid artery restenosis is a significant long-term complication of carotid endarterectomy. Carotid artery restenosis is the result of neointimal hyperplasia in the early postoperative period or recurrent atherosclerotic lesions in the following period. Numerous studies have incriminated several risk factors as predisposing conditions for restenosis. The definite role of each predisposing factor, however, is still widely debated. Aim: Investigation of frequency and risk factors for restenosis after carotid endarterectomy. Material and methods: Data of 295 patients who underwent carotid endarterectomy was reviewed between 2008 and 2010. Postoperative duplex studies were performed on control examinations in the following period between 2011 and 2019. Retrospective analysis was performed to assess the effect of demographic, clinical and laboratory characteristics of patients on the development of restenosis after carotid endarterectomy. Results: Restenosis occurred in 76 (26%) patients after carotid endarterectomy, with the highest incidence during the third (33%) and fourth (25%) year of follow-up. Patients with diabetes (p = 0.048) and peripheral arterial occlusive disease (p = 0.041) had significant statistical correlation with the occurrence of restenosis, as well as parameters of lipid status - cholesterol values (p = 0.025), serum low-density lipoprotein (p = 0.036) and non highdensity lipoprotein (p = 0.041). Conclusion: The results of our study confirm the significant role of atherosclerotic risk factors in the development of carotid artery restenosis in the later postoperative period. More frequent monitoring and control of systemic risk factors in these patients is necessary in order to prevent the development of carotid artery restenosis.
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