眼红斑痤疮患者的临床表现、随访及治疗效果。

IF 1.1 Q3 OPHTHALMOLOGY
I. Muftuoglu, Y. Akova
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引用次数: 9

摘要

目的:报道眼红斑痤疮患者的临床特点、治疗方案及并发症。材料与方法:回顾性分析24例48眼酒渣鼻患者的临床资料。根据病情严重程度对患者眼部体征和症状进行1 ~ 4分评分;记录治疗前后泪膜破裂时间(BUT)和Schirmer试验结果。所有患者均采用无防腐剂人工泪液、外用抗生素滴眼液/软膏、短期外用皮质类固醇、外用0.05%环孢素和口服强力霉素作为标准治疗。根据需要给予额外的治疗。记录并发症。结果:24例患者平均年龄为48.5±35.4(32-54)岁,随访时间平均为15±9.4(8-36)个月。眼部表现为睑板炎100%,前睑炎83%(40眼),点状角膜病变67%(32眼),眼睑脱落50%(24眼),角膜新生血管形成50%(24眼),上皮下浸润16.6%(8眼)。所有患者经治疗后症状和临床表现均有显著改善。Schirmer试验和BUT分别升高3.3±1.5和4.5±2.8 (p<0.05)。2眼角膜脱出、小穿孔;通过组织粘接剂(1只眼)和羊膜移植(1只眼)实现了双眼的再上皮化。局部贝伐单抗治疗后,3例患者的4只眼角膜新生血管明显消退。结论:眼酒渣鼻可表现为多种眼部体征。通过适当的治疗方式,包括局部皮质类固醇、局部环孢素和全身强力霉素,可以控制眼部疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical Findings, Follow-up and Treatment Results in Patients with Ocular Rosacea.
OBJECTIVES: To report the clinical features, treatment options and complications in patients with ocular rosacea. MATERIALS AND METHODS: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients' ocular signs and symptoms were scored between 1 and 4 points according to disease severity; tear film break-up time (BUT) and Schirmer's test results were recorded before and after the treatment. Preservative-free artificial tears, topical antibiotic eye drops/ointments, short-term topical corticosteroids, topical 0.05% cyclosporine and oral doxycycline treatment were applied as a standard therapy to all patients. Additional treatments were given as needed. Complications were recorded. RESULTS: Twenty-four patients with a mean age of 48.5±35.4 (32-54) years were followed for a mean 15±9.4 (8-36) months. Ocular findings included meibomitis in 100% of cases, anterior blepharitis in 83% (40 eyes), punctate keratopathy in 67% (32 eyes), chalazia in 50% (24 eyes), corneal neovascularization in 50% (24 eyes) and subepithelial infiltrates in 16.6% (8 eyes). Significant improvement of symptoms and clinical findings were achieved in all patients with treatment. The increases in Schirmer's test and BUT were 3.3±1.5 and 4.5±2.8, respectively (p<0.05). Descemetocele and small corneal perforation occurred in 2 eyes; re-epithelialization was achieved in both eyes with tissue adhesive application (1 eye) and additional amniotic membrane transplantation (1 eye). Four eyes of three patients showed significant regression of corneal neovascularization with topical bevacizumab therapy. CONCLUSION: Ocular rosacea may present with a variety of ophthalmic signs. It is possible to control the ophthalmic disease with appropriate therapeutic modalities including topical corticosteroids, topical cyclosporine and systemic doxycycline.
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