Impact from Early Rings on Rings of Maladjustment in Autism

In ASDs, starting with genetic vulnerabilities which may arise from adaptive mental edging changes on one hand, and perturbed microbiota-gut-brain axis on the other hand, the prenatal setup forms a body core that is in general labile and prone to both mental and physical conditions with functional impairments. The internal processes and external behavior of the brain and body in a self-organized system are mal-set as developmental atypicalities with notable mood and disruptive behavior problems in the neurodevelopmental domain. Modified neuronal networks since early-life depend on the environment and energy/resources provision as well as individual potential and self-regulatory setup for remodeling for emotive or motive activities as these contribute to social engagement, cognitive, social, and emotional growth. The postnatal makeup in ASD is altered during the stages of development from both mental and physical impairments whereby a complexity of atypicalities is developed. Layer upon layer, the rings on rings of maladjustments impair matching capabilities, starting early with visuomotor coordination impairment, suboptimal resource functioning, guarded food selectivity, with related defensive behavior, atypical reward-seeking behavior, and self-stimulatory drives depending on severity. More atypicalities may be derived and evolve further with related guarded social behavior, altered emotion-guided attention in ASD children that may evolve into emotion-evading behaviors, and altered self-relevant reward system that dampens the rewarding nature of social interaction and cognition. Depending on the degree of involvement, this early setup from both mental and physical causality leads to the final ASD symptom complex. This reemphasizes the consideration of physical functional problems, which isolated consideration could have distracted past studies with all along difficulties for finding pathogenesis of ASD. This paper describes the whole problem where the parts aggregate into rings, when rings locked in with another ring, to understand from the parts how they make up the whole