Hassan Abdulwahab Al-Shamahy, Sami Mohammed Abdo Hassan
{"title":"也门精神分裂症患者中人类白细胞抗原-DR/DQ多态性与精神分裂症的潜在关系","authors":"Hassan Abdulwahab Al-Shamahy, Sami Mohammed Abdo Hassan","doi":"10.5001/omj.2024.46","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the hypothesis that human leukocyte antigens (HLAs) confer susceptibility to schizophrenic disorders, by assessing their contribution to the risk of schizophrenia in a Yemeni population.</p><p><strong>Methods: </strong>The researchers approached patients who had been diagnosed with schizophrenia at Al-Amal Hospital for Psychiatric Diseases, Sana'a. Controls were drawn randomly from the general population. The HLA class II alleles of the participants were examined. The genotypes of the HLA-DQB1 and HLA-DRB1 alleles were determined by polymerase chain reaction using sequence-specific primers.</p><p><strong>Results: </strong>The subjects comprised 110 patients with schizophrenia, matched by an equal number of controls. The prevalence of HLA-DRB1*04 was significantly higher among patients than among controls (7.3% vs. 0.0%; <i>p =</i>0.003), as was HLA-DRB1*07 (62.7% vs. 17.3%, odds ratio (OR) = 8.1, 95% CI: 4.3-15.1; <i>p</i> < 0.001). HLA-DRBI*14 was significantly less prevalent among patients (0.9% vs. 11.8%, OR = 0.06, 95% CI: 0.01-0.50, χ<sup>2</sup> = 10.9; <i>p</i> < 0.001). HLA-DQB1*07 was the most common allele discovered in schizophrenia patients and was found to have a much higher incidence in patients than the control group (22.7% vs. 4.5%, OR = 6.2, 95%CI: 2.3-16.8, χ<sup>2</sup> = 15.4; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The HLA-DQB1 and HLA-DRB1 gene loci are linked to schizophrenia in the Yemeni population, according to the current study's evidence.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e590"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246548/pdf/","citationCount":"0","resultStr":"{\"title\":\"Potential Involvement of Human Leukocyte Antigen-DR/DQ Polymorphisms with Schizophrenia Among Patients with Schizophrenia in Yemen.\",\"authors\":\"Hassan Abdulwahab Al-Shamahy, Sami Mohammed Abdo Hassan\",\"doi\":\"10.5001/omj.2024.46\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To evaluate the hypothesis that human leukocyte antigens (HLAs) confer susceptibility to schizophrenic disorders, by assessing their contribution to the risk of schizophrenia in a Yemeni population.</p><p><strong>Methods: </strong>The researchers approached patients who had been diagnosed with schizophrenia at Al-Amal Hospital for Psychiatric Diseases, Sana'a. Controls were drawn randomly from the general population. The HLA class II alleles of the participants were examined. The genotypes of the HLA-DQB1 and HLA-DRB1 alleles were determined by polymerase chain reaction using sequence-specific primers.</p><p><strong>Results: </strong>The subjects comprised 110 patients with schizophrenia, matched by an equal number of controls. The prevalence of HLA-DRB1*04 was significantly higher among patients than among controls (7.3% vs. 0.0%; <i>p =</i>0.003), as was HLA-DRB1*07 (62.7% vs. 17.3%, odds ratio (OR) = 8.1, 95% CI: 4.3-15.1; <i>p</i> < 0.001). HLA-DRBI*14 was significantly less prevalent among patients (0.9% vs. 11.8%, OR = 0.06, 95% CI: 0.01-0.50, χ<sup>2</sup> = 10.9; <i>p</i> < 0.001). HLA-DQB1*07 was the most common allele discovered in schizophrenia patients and was found to have a much higher incidence in patients than the control group (22.7% vs. 4.5%, OR = 6.2, 95%CI: 2.3-16.8, χ<sup>2</sup> = 15.4; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The HLA-DQB1 and HLA-DRB1 gene loci are linked to schizophrenia in the Yemeni population, according to the current study's evidence.</p>\",\"PeriodicalId\":19667,\"journal\":{\"name\":\"Oman Medical Journal\",\"volume\":\"1 1\",\"pages\":\"e590\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246548/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oman Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5001/omj.2024.46\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oman Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5001/omj.2024.46","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
目的：通过评估人类白细胞抗原（HLAs）对也门精神分裂症风险的影响，评估人类白细胞抗原（HLAs）易患精神分裂症的假设：通过评估人类白细胞抗原（HLAs）对也门人群精神分裂症风险的影响，评估人类白细胞抗原（HLAs）导致精神分裂症易感性的假设：研究人员接触了萨那市 Al-Amal 精神病医院的精神分裂症患者。对照组从普通人群中随机抽取。对参与者的 HLA II 类等位基因进行了检测。使用序列特异性引物通过聚合酶链反应测定 HLA-DQB1 和 HLA-DRB1 等位基因的基因型：结果：研究对象包括 110 名精神分裂症患者和同等数量的对照组。患者中HLA-DRB1*04的患病率明显高于对照组（7.3% vs. 0.0%; p =0.003），HLA-DRB1*07的患病率也明显高于对照组（62.7% vs. 17.3%, odds ratio (OR) = 8.1, 95% CI: 4.3-15.1; p <0.001）。HLA-DRBI*14在患者中的发病率明显较低（0.9% vs. 11.8%，OR = 0.06，95% CI：0.01-0.50，χ2 = 10.9；P < 0.001）。HLA-DQB1*07是精神分裂症患者中最常见的等位基因，其发病率远高于对照组（22.7% vs. 4.5%，OR = 6.2，95%CI：2.3-16.8，χ2 = 15.4；P < 0.001）：结论：根据目前的研究证据，HLA-DQB1 和 HLA-DRB1 基因位点与也门人群中的精神分裂症有关。
Potential Involvement of Human Leukocyte Antigen-DR/DQ Polymorphisms with Schizophrenia Among Patients with Schizophrenia in Yemen.
Objectives: To evaluate the hypothesis that human leukocyte antigens (HLAs) confer susceptibility to schizophrenic disorders, by assessing their contribution to the risk of schizophrenia in a Yemeni population.
Methods: The researchers approached patients who had been diagnosed with schizophrenia at Al-Amal Hospital for Psychiatric Diseases, Sana'a. Controls were drawn randomly from the general population. The HLA class II alleles of the participants were examined. The genotypes of the HLA-DQB1 and HLA-DRB1 alleles were determined by polymerase chain reaction using sequence-specific primers.
Results: The subjects comprised 110 patients with schizophrenia, matched by an equal number of controls. The prevalence of HLA-DRB1*04 was significantly higher among patients than among controls (7.3% vs. 0.0%; p =0.003), as was HLA-DRB1*07 (62.7% vs. 17.3%, odds ratio (OR) = 8.1, 95% CI: 4.3-15.1; p < 0.001). HLA-DRBI*14 was significantly less prevalent among patients (0.9% vs. 11.8%, OR = 0.06, 95% CI: 0.01-0.50, χ2 = 10.9; p < 0.001). HLA-DQB1*07 was the most common allele discovered in schizophrenia patients and was found to have a much higher incidence in patients than the control group (22.7% vs. 4.5%, OR = 6.2, 95%CI: 2.3-16.8, χ2 = 15.4; p < 0.001).
Conclusions: The HLA-DQB1 and HLA-DRB1 gene loci are linked to schizophrenia in the Yemeni population, according to the current study's evidence.
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