天然和人工食品添加剂对荨麻疹的反应:我们应该假装它们不存在吗?

IF 0.2 Q4 ALLERGY
B. Sadowska, Marlena Sztormowska, Marika Gawinowska, M. Chełmińska
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引用次数: 0

摘要

导言:对食品添加剂过敏仍在调查中。目的:了解荨麻疹患者及疑似食品添加剂过敏患者对食品添加剂的反应发生率及其临床意义。材料和方法:该研究纳入了2017-2019年在格但斯克医科大学过敏学和肺炎科住院的疑似对食品添加剂过敏的患者。研究中选择了以下物质:焦亚硫酸钠、胭脂红、红木、谷氨酸钠、苯甲酸钠和偶氮染料的混合物。诊断过程采用标准化问卷、皮肤点刺试验、斑贴试验和胭脂红sIgE水平评估。所有皮肤试验阳性、sIgE水平升高或疑似对食品添加剂过敏的患者都符合单盲安慰剂对照口服刺激的条件。结果:110例患者入组研究。在进行的171项挑战中,22名受试者中有25项是阳性的。结论:食品添加剂可在IgE依赖性和非IgE依赖性机制中加剧和诱发过敏反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reactions after natural and artificial food additives in urticaria: should we pretend they do not exist?
Introduction: Hypersensitivity to food additives is still under investigation. Aim: To evaluate the incidence of reactions to food additives and their clinical significance in urticaria patients and suspected hypersensitivity to them. Material and methods: The study included patients hospitalized at the Department of Allergology and Pneumology of the Medical University of Gdansk in 2017–2019 with suspected hypersensitivity to food additives. The following substances were selected for the study: sodium metabisulfite, carmine, annatto, monosodium glutamate, sodium benzoate, and a mixture of azo dyes. A standardized questionnaire, skin prick tests, patch tests, and sIgE level evaluation for carmine were used in the diagnostic procedure. All the patients with positive skin testing, elevated sIgE level or suspected hypersensitivity for food additives were qualified for the single-blind placebo-controlled oral challenge. Results: One hundred and ten patients were enrolled in the study. Out of 171 challenges carried out, 25 were positive in 22 subjects. Conclusions: Food additives can exacerbate and induce hypersensitivity reactions in IgE- and non-IgE-de-pendent mechanisms.
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来源期刊
自引率
50.00%
发文量
18
期刊介绍: Alergologia Polska - Polish Journal of Allergology is aimed mainly at allergologists, but also medical doctors working in related fields, such as otolaryngology, pulmonology, and dermatology. The main goal of the journal is to ensure rapid publication of important research papers and interesting case studies from the following areas: allergology, diagnostics, therapy of allergic diseases, in particular in the area of immunotherapy, rhinitis, asthma. The Editorial Board accepts for publication original papers, case studies and letters to the Editor. We also publish review articles (both commissioned and those agreed upon with the Editor-in-Chief), articles dealing with standards of medical practice, as well as special issues. The journal is published quarterly. We guarantee short review times (up to two weeks) and immediate publication on-line upon Editor acceptance.
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