{"title":"ABO型minor mismatch活体肝移植后抗B抗体长期迁延的1例病例","authors":"忍 藤井, 正浩 桝屋, 由美 田中, 古川 美津子, 葛西 千枝子, 憲行 信田, 信行 南, 伸二 上本","doi":"10.3925/JJTC1958.50.626","DOIUrl":null,"url":null,"abstract":"We report a case of hemolytic anemia due to anti-B antibody after minor ABO-mismatched partial liver transplantation from a living donor. The patient was a 5-year-old girl with congenital biliary atresia, and group AB, Rh-positive blood. A partial liver transplant from her group A, D (Rh0) mother was performed. The recipient HLA was A2, 26; B54, 62; DR4, 15, and that of the donor was A2, -; B54, -; DR4, 14. This type of transplantation is the so-called one-way donor-recipient HLA matching. Her hemoglobin fell rapidly from 11.0g/dl to 6.0g/dl between days 10 and 15 after liver transplantation without evidence of bleeding. On day 14, anti-B IgM antibody was found in her serum. On day 16, two units of group O washed red blood cells were transfused, after which no further transfusions were required. This anti-B IgM antibody was thought to be produced from passenger B lymphocytes in the donor's liver. Although this type of antibody usually disappears within 4 weeks, it was continuously detected for about 4 months in this case. The long-term presence of anti-B antibody may be caused by one-way donor-recipient HLA matching.","PeriodicalId":86521,"journal":{"name":"Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion","volume":"50 1","pages":"626-630"},"PeriodicalIF":0.0000,"publicationDate":"2004-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ABO型 minor mismatch 生体肝移植後に抗B抗体が長期間遷延した1症例\",\"authors\":\"忍 藤井, 正浩 桝屋, 由美 田中, 古川 美津子, 葛西 千枝子, 憲行 信田, 信行 南, 伸二 上本\",\"doi\":\"10.3925/JJTC1958.50.626\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We report a case of hemolytic anemia due to anti-B antibody after minor ABO-mismatched partial liver transplantation from a living donor. The patient was a 5-year-old girl with congenital biliary atresia, and group AB, Rh-positive blood. A partial liver transplant from her group A, D (Rh0) mother was performed. The recipient HLA was A2, 26; B54, 62; DR4, 15, and that of the donor was A2, -; B54, -; DR4, 14. This type of transplantation is the so-called one-way donor-recipient HLA matching. Her hemoglobin fell rapidly from 11.0g/dl to 6.0g/dl between days 10 and 15 after liver transplantation without evidence of bleeding. On day 14, anti-B IgM antibody was found in her serum. On day 16, two units of group O washed red blood cells were transfused, after which no further transfusions were required. This anti-B IgM antibody was thought to be produced from passenger B lymphocytes in the donor's liver. Although this type of antibody usually disappears within 4 weeks, it was continuously detected for about 4 months in this case. The long-term presence of anti-B antibody may be caused by one-way donor-recipient HLA matching.\",\"PeriodicalId\":86521,\"journal\":{\"name\":\"Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion\",\"volume\":\"50 1\",\"pages\":\"626-630\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3925/JJTC1958.50.626\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3925/JJTC1958.50.626","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
We report a case of hemolytic anemia due to anti-B antibody after minor ABO-mismatched partial liver transplantation from a living donor. The patient was a 5-year-old girl with congenital biliary atresia, and group AB, Rh-positive blood. A partial liver transplant from her group A, D (Rh0) mother was performed. The recipient HLA was A2, 26; B54, 62; DR4, 15, and that of the donor was A2, -; B54, -; DR4, 14. This type of transplantation is the so-called one-way donor-recipient HLA matching. Her hemoglobin fell rapidly from 11.0g/dl to 6.0g/dl between days 10 and 15 after liver transplantation without evidence of bleeding. On day 14, anti-B IgM antibody was found in her serum. On day 16, two units of group O washed red blood cells were transfused, after which no further transfusions were required. This anti-B IgM antibody was thought to be produced from passenger B lymphocytes in the donor's liver. Although this type of antibody usually disappears within 4 weeks, it was continuously detected for about 4 months in this case. The long-term presence of anti-B antibody may be caused by one-way donor-recipient HLA matching.
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