{"title":"癫痫和自闭症","authors":"M. Coleman","doi":"10.4172/2472-0895.1000E101","DOIUrl":null,"url":null,"abstract":"Epilepsy and autism have a strong association. The hypothesis of excitatory/inhibitory imbalance first developed in epilepsy is now under serious consideration in autism. Such a hypothesis might help explain why 30% of individuals with one of The Autisms, many of them not yet diagnosed with their underlying disease entity, have a seizure disorder; this is a figure higher than is found even in severely retarded individuals. There are at least 35 diagnosed disease entities with autism/ epilepsy described in the medical literature [1] and now that the cost of genome sequencing has dropped to an affordable range, undoubtedly many more will be identified.","PeriodicalId":81656,"journal":{"name":"Journal of epilepsy","volume":"1 1","pages":"1-1"},"PeriodicalIF":0.0000,"publicationDate":"2015-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Epilepsy and the Autisms\",\"authors\":\"M. Coleman\",\"doi\":\"10.4172/2472-0895.1000E101\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Epilepsy and autism have a strong association. The hypothesis of excitatory/inhibitory imbalance first developed in epilepsy is now under serious consideration in autism. Such a hypothesis might help explain why 30% of individuals with one of The Autisms, many of them not yet diagnosed with their underlying disease entity, have a seizure disorder; this is a figure higher than is found even in severely retarded individuals. There are at least 35 diagnosed disease entities with autism/ epilepsy described in the medical literature [1] and now that the cost of genome sequencing has dropped to an affordable range, undoubtedly many more will be identified.\",\"PeriodicalId\":81656,\"journal\":{\"name\":\"Journal of epilepsy\",\"volume\":\"1 1\",\"pages\":\"1-1\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of epilepsy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2472-0895.1000E101\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of epilepsy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2472-0895.1000E101","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Epilepsy and autism have a strong association. The hypothesis of excitatory/inhibitory imbalance first developed in epilepsy is now under serious consideration in autism. Such a hypothesis might help explain why 30% of individuals with one of The Autisms, many of them not yet diagnosed with their underlying disease entity, have a seizure disorder; this is a figure higher than is found even in severely retarded individuals. There are at least 35 diagnosed disease entities with autism/ epilepsy described in the medical literature [1] and now that the cost of genome sequencing has dropped to an affordable range, undoubtedly many more will be identified.
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