当前糖组学的方法:子项目和期刊

V. Pomin
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引用次数: 3

摘要

在基因组、蛋白质组、代谢组和脂质组时代之后,生物学领域迎来了糖基因组时代,这比第一批“基因组”项目带来了更多的挑战。长期以来,碳水化合物只是一种能量相关的生物分子的主要概念(基本上直到80年代初)已经崩溃,因为无数其他重要的生物作用已经被记录下来。目前糖组学的蓬勃发展已经证明了这类分子在化学和生物学的许多领域的重要性。现在关于碳水化合物的生物作用的数据量非常高,结果证明不可能一次将所有类型的作用结合起来。这些作用不仅涉及细胞[2]的生长、迁移、分化或信号事件,或生理学[2]的免疫学、血液学和组织学,而且在不同的背景下,碳水化合物也可以作为抗凝血、抗血栓、抗炎、抗病毒、抗致病、抗肿瘤、抗转移、抗血管生成剂等生物医学应用,以及其他治疗用途[3,4]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current Glycomics' Approaches: Subprojects and Journals
After the era of genome, proteome, metabolome, and lipidome, the age of glycome has launched in biology bringing so far more challenges than the first “ome” projects. The long major conception of carbohydrates as just energetically involved class of biomolecules (basically until early 80’s) has fallen apart as innumerable other essential biological roles have been documented. The current glycomics’ boom [1] has been proving the importance of this class of molecules in many fields regarding the sciences of chemistry and biology. And nowadays the amount of data concerning biological actions of carbohydrates is very high which turned out to be impossible to enlist all types of action together at once. Such actions involve not only essential roles in cell [2] like growth, migration, differentiation or signaling events, or in physiology [2] like immunology, hematology, and histology, but within a different context, carbohydrates can also exhibit potent biomedical applications as anticoagulant, antithrombotic, anti-inflammatory, antivirotic, antipathogenic, antitumorigenic, antimetastatic, antiangiogenic agents, among other therapeutic uses [3,4].
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