de Galo (Celtis iguanaea, Jacq.)的安全性评价叶片粗提物:雄性大鼠急性和亚急性毒性研究

Silva Arh, Froeder Alf, K. C. Figueredo, Noda Jm, R. BorbadeFreitas, L. Nunes, L. Pappis, A. Boligon, Cardoso Ms, R. Moresco, M. Veiga, AthaydeML, L. Bauermann, G. Hubscher
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引用次数: 2

摘要

鬣蜥通常被葡萄牙语称为“Esporao-de-galo”,其叶子传统上用于输液形式,具有镇痛、平喘、消化和利尿剂的作用。本研究的目的是评价蛇麻叶粗提物对雄性大鼠的急性和亚急性毒性。毒性研究是根据经济合作与发展组织(经合组织-准则423和407)的准则进行的。在急性研究中,给药剂量为2000 mg/kg,单次口服。在亚急性研究中,雄性大鼠分别以100、200和400 mg/kg/d的剂量口服提取物,持续28天。行为改变及生化、血液学和组织学分析。急性给药鬣蜥没有引起行为或死亡的变化。在亚急性毒性研究中,我们观察到葡萄糖升高和天冬氨酸转氨酶(ASAT)酶降低。根据经济合作与发展组织的指南,经急性给药后,鬣鳞草可能被归类为安全(5类)。然而,亚急性给药后观察到的变化表明,需要更多的研究来阐明其作用机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Safety Assessment of Esporão de Galo (Celtis iguanaea (Jacq.) Sargent) Crude Extract from Leaves: Acute and Subacute Toxicity Studies in Male Rats
Celtis iguanaea is popularly known as “Esporao-de-galo” in Portuguese and its leaves are traditionally used in infusion forms as analgesic, antiasthmatic, digestive and diuretic. The aim of this study was to assess the acute and sub-acute toxicity of the crude extract from the Celtis iguanaea leaves in male rats. The toxicity studies were based on the guidelines of the Organization for Economic Cooperation and Development (OECD-guidelines 423 and 407). In the acute study, a single dose of 2000 mg/kg of C. iguanaea was administered orally. In the sub-acute study, the extract was administered orally to male rats with doses of 100, 200 and 400 mg/kg/day for 28 days. Behavioral changes and biochemical, hematological, and histological analysis were evaluated. The acute administration of C. iguanaea did not cause changes in behavior or mortality. At the sub-acute toxicity study, we observed an increase of glucose and a decrease of the aspartate aminotransferase (ASAT) enzyme. Celtis iguanaea, after acute administration, may be classified as safe (category 5), according to the OECD guide. However, the alterations observed after sub-acute administration with high doses of crude extract from the C. iguanaea leaves suggest that more studies are needed to elucidate the mechanism of action.
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