吡格列酮对高血压合并糖耐量受损患者血流介导的内皮依赖性舒张功能的影响

国际医药卫生导报 Pub Date : 2014-11-15 DOI:10.3760/CMA.J.ISSN.1007-1245.2014.22.006

Ming Xiao, Yi Xie, Song-tao Zhan, Baocheng Zhang

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引用次数: 0

摘要

目的通过比较吡格列酮治疗前后对原发性高血压(EH)和糖耐量受损(IGT)患者血流介导的内皮依赖性舒张功能(FMD)的影响，探讨吡格列酮治疗前后FMD的影响。方法68例EHI患者，对照组仅接受降压治疗、体育锻炼和饮食控制。测定患者血压、空腹血糖(FPG)、空腹胰岛素(FINS)、餐后2小时血糖(2hPG)、糖化血红蛋白(HbA1c)、血脂、胰岛素抵抗指数[IRI,IRI =(FPG × FINS)/22.5]、FMD。结果吡格列酮组治疗后FMD明显改善[(10.38±2.45)比(8.96±2.29)，P < 0.05]，对照组治疗前后差异无统计学意义[(8.83±2.38)比(9.08±2.49)，P < 0.05]。结论吡格列酮降低胰岛素抵抗和2hPG，增强FMD。关键词:原发性高血压;葡萄糖耐量受损;吡格列酮;血流介导的内皮依赖性扩张功能

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The effect of Pioglitazone on flow mediated endothelium-dependent dilatation function in patients with essential hypertension and impaired glucose tolerance

Objective To study the effect of Pioglitazone on flow mediated endothelium-dependent dilatation function (FMD) in patients with essential hypertension (EH) and impaired glucose tolerance (IGT) by comparing FMD before and after the therapy of Pioglitazone.Methods 68 patients with EHI while control group received anti-hypertension therapy,physical exercise and diet control only.Measured patients' blood pressure,fasting plasma glucose (FPG),fasting insulin (FINS),2 hours postprandial plasma glucose (2hPG),glycated hemoglobin (HbA1c),blood fat,insulin resistance index [IRI,IRI =(FPG × FINS)/22.5],FMD.Results FMD improved significantly after treatment in Pioglitazone group [(10.38 ± 2.45) vs.(8.96 ± 2.29),P ＜ 0.05],there was no statistically significant difference before and after treatment in control group [(8.83 ± 2.38) vs.(9.08 ± 2.49),P ＞ 0.05].Conclusion Pioglitazone reduced insulin resistance and 2hPG,enhanced FMD. Key words: Essential hypertension; Impaired glucose tolerance; Pioglitazone; Flow mediated endothelium-dependent dilatation function

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国际医药卫生导报

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