Predictive value of cervical fetal fibronectin in the first trimester pregnancy outcome of recurrent spontaneous abortion

Objective To discuss the clinical value of fetal fibronectin when predicting the first-trimester fatal loss in recurrent miscarriage.Methods We measured fetal fibronectin concentrations in cervical and vaginal secretions in 84 cases of recurrent miscarriage admitted in our hospital from 2008 to 2011 as observation group.And we also tested it in 31 uncomplicated pregnant women.Tests were given in first-trimester.Age and previous miscarriage number were also compared.Follow-up was given till 14 weeks of pregnancy.Results In observation group,57.14％ of patients were tested by positive fFN results,while in control group,the percentage reduced to 12.90％.It had statistical significant difference (P ＜ 0.01).In positive fFN patients,29.17％ leaded to fatal loss in observation group,while 8.33％ in control group (P ＜ 0.05).The sensitivity and accuracy for predicting miscarriage by fFN test in recurrent miscarriage in first-trimester were 82.35％ and 49.25％.Positive fFN could be found more in women over 35 years old and in women under age of 35 years.Conclusion The presence of cervicovaginal fetal fibronectin in the second and third trimesters of pregnancy identifies a subgroup of women who are at high risk of recurrent miscarriage.The measure of cervical fetal fibronectin had great sensitivity in first-trimester to predict the fatal loss,particularly for women aged over 35 years. Key words: Fetal fibronectin;  Recurrent spontaneous abortion;  Early pregnancy