Impact of lipoic acid on lesion density and surrounding edema of patients with acute cerebral infarction

Objective To discuss and analyze the impact of lipoic acid on lesion density and surrounding edema of patients with acute cerebral infarction (ACI).Methods 60 patients with ACI in our hospital from March 2012 to March 2014 were chosen and divided into two groups with 30 cases in each group according to random single-blind principle.Control group was treated with routine treatment,while observation group was treated with intravenous drip of lipoic acid injection on the basis of routine treatment.Clinical effect,lesions and surrounding edema area change and adverse drug reaction of two groups were compared.Results The effective rate of observation group was obviously higher than that of control group (86.7％ vs.60.0％).On the 7th day of treatment,CT value of observation group obviously increased,and lesions and edema area obviously decreased; CT value of control group obviously decreased,and lesions and edema area obviously increased; CT value of observation group was obviously higher than that of control group,and lesions and edema area were obviously smaller than those of control group (P ＜ 0.05).Conclusion Lipoic acid has a good curative effect in the treatment of ACI,which can effectively improve CT value,improve relative area without lesion and decrease edema area,so it is safe and reliable. Key words: Lipoic acid;  Acute cerebral infarction;  Lesions;  Edema