聚氯乙烯基膜新型聚合物电极测定盐酸阿米洛利药物的研究与构建

Q4 Medicine

Journal of Cardiovascular Disease Research Pub Date : 2019-01-01 DOI:10.33422/2nd.icarbme.2019.12.945

S. A. Abrahem, S. Ibrahim, A. Kader

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引用次数: 0

摘要

以盐酸阿米洛利-甲基橙为基材，在聚氯乙烯基质中作为离子对络合物构建了两个盐酸阿米洛利电极。用硝基苯(NB)和磷酸二丁酯(DBP)进行塑化。Amiloride hydrochloride (AMH)电极(e1和e2)的斜率分别为54.210和52.810 mV/decade，线性范围分别为10-5-10-2和2*10-5-10-2 M。以DBP增塑剂为基材，优选电极(e1)。检测限为4x10-6M，斜率为54.210 mV/ 10年，相关系数0.9998，寿命36天。该电极重现性好，稳定性好，可用于药品样品中盐酸阿米洛利的测定。研究了(Na+， Cu+2, K+， Fe+3, Mn+2)干扰测量的选择性系数，分别采用分离法和混合法测定

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Study and Construction of New Polymeric Electrodes in PVC Matrix Membrane for Amiloride Hydrochloride Drug Determination

Based on Amiloride hydrochloride-methyl orange, two electrodes of Amiloride hydrochloride were constructed in PVC matrix as ion pair complex. They were plasticized using Nitrobenzene (NB), and Di-butyl phosphate (DBP). Amiloride hydrochloride (AMH) electrodes (e1and e2) presented slopes (54.210 and 52.810 mV/decade) and linear ranges (10-5-10-2, and 2*10-5-10-2 M), respectively. (e1), which is the best electrode, was based on DBP plasticizer. It gave a detection limit of 4x10-6M, slope of 54.210 mV/decade, correlation coefficient 0.9998, lifetime 36 days. The proposed electrode displayed reproducibility and good stability and was used for determining Amiloride hydrochloride in pharmaceutical samples. The interference measurements using (Na+, Cu+2, K+, Fe+3, and Mn+2) were studied for selectivity coefficient determination using the separated method, as well as the mixed method

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来源期刊

Journal of Cardiovascular Disease Research Medicine-Cardiology and Cardiovascular Medicine

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