Yang Lu, Chun Lai, Pingang Lu, Yuewen Peng, Z. Bao, Hongmin Luo
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Acupuncture Treatment for Insomnia and its Effect on Serum TNF-α, IL-6, and IL-1β levels
The incidence of insomnia is increasing, and acupuncture is known to have a favorable therapeutic effect on insomnia, but its treatment mechanism is unclear. Patients with insomnia were recruited and randomly divided into an acupuncture treatment group and a control group using a single-blind, random number table. The Pittsburgh Sleep Quality Index (PSQI) score, Insomnia Severity Index (ISI) score, sleep-related parameters (SE, SA, and TST), and levels of inflammatory response factors IL-1β, IL-6, and TNF-α were analyzed. The baseline data of the two groups were not significantly different and were comparable. Acupuncture treatment significantly improved patient PSQI (P < 0.05) and ISI scores (P < 0.05), as well as SE, SA, and TST (P < 0.05). Levels of TNF-α and IL-1β were increased (all P < 0.05), while IL-6 levels were decreased (P < 0.05), lasting for at least 4 weeks. Acupuncture treatment can increase the serum levels of TNF-α and IL-1β, decrease IL-6 levels, and improve insomnia symptoms.
期刊介绍:
The aim of the journal is to provide an international forum for the exchange of ideas and promotion of basic and clinical research in acupuncture, electro-therapeutics, and related fields. The journal was established in order to make acupuncture and electro-therapeutics a universally acceptable branch of medicine through multidisciplinary research based on scientific disciplines. The final goal is to provide a better understanding of both the beneficial and adverse effects of these treatments in order to supplement or improve existing methods of diagnosis, prognosis, treatment, and prevention of diseases in both Western and Oriental medicine.