eb病毒潜伏膜蛋白1在获得性免疫缺陷综合征相关弥漫性大b细胞淋巴瘤中的表达及意义

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Xiaoyun Tu, Ai-hua Deng, C. Sun, Yang Liu, Yu Chen, Y. Xiong
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The total positive rate of Epstein-Barr virus-latent membrane protein 1 was 77.3 % in human immunodeficiency virus-related diffuse large B-cell lymphomas and 71.4 % in non-human immunodeficiency virus-related diffuse large B-cell lymphomas. Most related diffuse large B-cell lymphomas cells showed nuclear staining pattern and the nuclear positive rate was 82.4 % in human immunodeficiency virus-related diffuse large B-cell lymphomas and 60 % in non-human immunodeficiency virus-related diffuse large B-cell lymphomas. There was no significant difference between human immunodeficiency virus-related diffuse large B-cell lymphomas and non-human immunodeficiency virus-related diffuse large B-cell lymphomas. The expression of Epstein-Barr virus-latent membrane protein 1 was significant between human immunodeficiency virus-related diffuse large B-cell lymphomas and benign lesion. 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Expression and Significance of Epstein-Barr Virus-Latent Membrane Protein 1 in Acquired Immune Deficiency Syndrome-Related Diffuse Large B-Cell Lymphoma
We aimed to investigate the expression and significance of Epstein-Barr virus-latent membrane protein 1 in human immunodeficiency virus-related diffuse large B-cell lymphomas. 22 cases of human immunodeficiency virus-related diffuse large B-cell lymphomas samples were collected. The control group consisted of 7 cases of non-human immunodeficiency virus-related diffuse large B-cell lymphomas, 6 cases of human immunodeficiency virus-reactive hyperplasia and 6 cases of non-human immunodeficiency virus. The expression of Epstein-Barr virus-latent membrane protein 1 was detected by immunohistochemistry and analyzed in combination with clinicopathology characteristics. The total positive rate of Epstein-Barr virus-latent membrane protein 1 was 77.3 % in human immunodeficiency virus-related diffuse large B-cell lymphomas and 71.4 % in non-human immunodeficiency virus-related diffuse large B-cell lymphomas. Most related diffuse large B-cell lymphomas cells showed nuclear staining pattern and the nuclear positive rate was 82.4 % in human immunodeficiency virus-related diffuse large B-cell lymphomas and 60 % in non-human immunodeficiency virus-related diffuse large B-cell lymphomas. There was no significant difference between human immunodeficiency virus-related diffuse large B-cell lymphomas and non-human immunodeficiency virus-related diffuse large B-cell lymphomas. The expression of Epstein-Barr virus-latent membrane protein 1 was significant between human immunodeficiency virus-related diffuse large B-cell lymphomas and benign lesion. Epstein-Barr virus-latent membrane protein 1 expression in non-germinal center B cell human immunodeficiency virus-related diffuse large B-cell lymphomas was significantly higher than that in germinal center B cell human immunodeficiency virus-related diffuse large B-cell lymphomas. However, Epstein-Barr virus-latent membrane protein 1 expression had no correlation with sex, age, location of tumor and clinical stage (p>0.05). Epstein-Barr virus-latent membrane protein 1 was mainly located in nuclear and overexpressed in human immunodeficiency virus-related diffuse large B-cell lymphomas and non-human immunodeficiency virus-related diffuse large B-cell lymphomas, suggesting that Epstein-Barr virus-latent membrane protein 1 overexpression was involved in tumourogenesis of related diffuse large B-cell lymphomas. Epstein-Barr virus-latent membrane protein 1 expression was correlated with immunophenotype of related diffuse large B-cell lymphomas. As the prognosis was different in different immunophenotype subgroups, Epstein-Barr virus-latent membrane protein 1 may be the potential marker of prognosis for human immunodeficiency virus-related diffuse large B-cell lymphomas.
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来源期刊
自引率
0.00%
发文量
0
审稿时长
2 months
期刊介绍: The Indian Journal of Pharmaceutical Sciences (IJPS) is a bi-monthly Journal, which publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences (Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Therapeutics, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmacovigilance, Pharmacoepidemiology, Pharmacoeconomics, Drug Information, Patient Counselling, Adverse Drug Reactions Monitoring, Medication Errors, Medication Optimization, Medication Therapy Management, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on current topics in Pharmaceutical Sciences are also considered for publication by the Journal.
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