磷酸替米考星在健康肉鸡体内的药动学参数

V. Dukhnitsky, V. Sokolyuk, A. Tishkovskaya, M. Tishkovskiy, I. Ligomina
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引用次数: 0

摘要

本文介绍了KOBB-500杂交健康肉鸡体内磷酸替米科星(Tilmox 25%的有效成分)的摄入(口服)、分布和排泄的研究结果。建立了磷酸盐替米考星从鸟类消化道快速吸收并进入内脏器官的作用。磷酸替米考星含量最高的部位为肺和肝。Tilmox 25%溶液开始施用后仅2小时(17.02±0.24和12.78±0.22 μg / g), 26小时后肾脏含量为8 25±0.19 μg / g, 52小时后胸肌和心肌含量分别为- 6.19±0.28和5.23±0.39 μg / g。健康鸟类服用Tilmox 25%溶液时,不伴有磷酸替米科星的积累(物质积累),因为其在鸟类内脏和肌肉中的含量不取决于药物使用的持续时间。Tilmox 25%溶液灌胃96 h,在肺中检测到磷酸替尔米科星的最高含量,表明其具有组织亲和性。当感染因子定位于家禽肺部时,以及治疗各种病因的呼吸系统疾病患者时,最大剂量的磷酸替米科星分布到肺部(“器官亲和性”或“组织趋向性”)是重要的。停止使用Tilmox 25%的同时,其活性物质磷酸替尔米科星在研究器官中的含量显著降低。停用替尔莫司溶液24小时(实验第120小时),与实验第96小时指标相比,肺、肝、肾、胸肌、心肌磷酸替尔米科星含量分别减少1.9倍、1.6倍、1.4倍、1.7倍、1.3倍。停用替尔莫司液后第5天(试验第216小时),各器官中磷酸替尔莫司的残留量为:肺- 1.20±0.03 μg / g;肝脏- 1.01±0.02;肾- 0.91±0.03 μg / g。在本研究期间,磷酸替米考辛的最低含量仅在心肌样品中的一个样品中- 0.02 μg / g,在胸肌中未检测到。关键词:Tilmox 25%,器官,分布,积累,排泄,药代动力学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacokinetic parameters of Tilmicosin Phosphate in the body of healthy broiler chickens
The article presents the results of studies of the intake (oral administration), distribution and excretion of Tilmicosin Phosphate (active ingredient of the Tilmox 25%) from the body of healthy broiler chickens of the KOBB-500 cross. The rapid absorption of Tilmicosin Phosphate from the alimentary tract of the birds and its entry into the internal organs was established. The maximum content of Tilmicosin Phosphate was found in the lungs and liver. Only in 2 hours after the beginning of the Tilmox 25% solution application, which was 17.02 ± 0.24 and 12.78 ± 0.22 μg / g, its content in the kidneys after 26 hours was 8 25 ± 0.19 μg / g, pectoral and cardiac muscles after 52 hours - 6.19 ± 0.28 and 5.23 ± 0.39 μg / g, respectively. Consumption of Tilmox 25% solution by a healthy bird was not accompanied by the accumulation of Tilmicosin Phosphate (material accumulation), since its content in the internal organs and muscles of the bird did not depend on the duration of the drug use. During 96 hours of Tilmox 25% solution consumption by broiler chickens the maximum content of Tilmicosin Phosphate was detected in the lungs, which indicates its tissue tropism. The distribution of Tilmicosin Phosphate in maximum amounts to the lungs ("organ affinity" or "tissue tropism") is important when infectious agents are localization in the lungs of poultry, as well as for the treatment of patients with respiratory diseases of various etiology. The cessation of the use of Tilmox 25% was accompanied by a significant decrease in the content of its active substance, Tilmicosin Phosphate, in the organs under study. Twenty-four hours after the cessation of consumption the tilmox solution (120 hours of the experiment), the content of Tilmicosin Phosphate in the lungs was 1.9 times less, liver – 1.6 times, kidneys – 1.4 times, pectoral muscle - 1.7 times, cardiac muscle – 1.3 times less, compared with indicators on 96 hours of experiment. Five days after the cessation of feeding the tilmox solution to broiler chickens (216 hours of the experiment), the residual amounts of Tilmicosin Phosphate in the organs under study were: in the lungs – 1.20 ± 0.03 μg / g; liver – 1.01 ± 0.02; kidneys - 0.91 ± 0.03 μg / g. The lowest content of Tilmicosin Phosphate, during this period of research, was only in one of the three samples of the heart muscle – 0.02 μg / g, and it was not detected in the pectoral muscle. Key words: Tilmox 25 %, organs, distribution, accumulation, excretion, pharmacokinetics.
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