新型(e)-2-苄基- n -(3-(3-氧-2,3-二氢-4- h -苯并[b][1,4]恶嗪-4-基)丙基)肼-1-碳硫酰胺类似物的体外抗增殖活性

IF 0.5 Q4 EDUCATION & EDUCATIONAL RESEARCH

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI:10.31788/rjc.2023.1628154

Palla Sai Lakshmi, P. Shankaraiah

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引用次数: 0

摘要

一种新的取代-(E)-2-苄基- n-(3-(3-氧-2,3-二氢- 4h -苯并[b][1,4]恶嗪-4-基)丙基)肼-1-碳硫酰胺(9a-j)的类似物在体外环境中具有抗增殖活性，一些新衍生的衍生物在生长抑制中显示出足够大的抑制肿瘤细胞数量50为0.180-4.20µM。化合物9a、9b、9d、9g、9i和9j对4种人肿瘤细胞系表现出良好的拮抗作用。其中9a和9g对IMR-32(人神经母细胞瘤细胞)和MIAPACA(人胰腺癌细胞)分别表现出0.23M和0.18M的促癌作用。值得注意的是，化合物9g对MIAPACA细胞株的活性分别为0.18M。

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IN VITRO ANTI-PROLIFERATIVE ACTIVITY OF NOVEL ANALOGUES OF(E)-2-BENZYLIDENE-N-(3-(3-OXO-2,3- DIHYDRO-4H-BENZO[B][1,4]OXAZIN-4-YL)PROPYL) HYDRAZINE-1-CARBOTHIOAMIDE

A novel analog of substituted-(E)-2-benzylidene-N-(3-(3-oxo-2,3-dihydro-4H-benzo[b] [1,4] oxazin-4-yl)propyl) hydrazine-1-carbothioamides (9a-j) appeared to be assess being anti-proliferative activity in vitro environment some of the newly derived derivatives have shown sufficiently great to modest suppression in the number of cells in cancer among GrowthInhibition50 was (0.180-4.20 µM). Compounds 9a, 9b, 9d, 9g, 9i, and 9j showed promising acts contrarily 4 human being tumor cell lines. Out of 9a and 9g displayed heartening cancer act in opposition to IMR-32 (Human being neuroblastoma cells) at 0.23 M and MIAPACA(human pancreatic carcinoma cells) at 0.18 M respectively. Notably, compound 9g showed significant activity at 0.18 M against the MIAPACA cell line respectively.

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来源期刊

Rasayan Journal of Chemistry Energy-Energy (all)

CiteScore

1.90

自引率

0.00%

发文量

196

期刊介绍： RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.