n -(5-溴-2-(5-苯基1,3,4-恶二唑-2-基)萘[2,1- b]呋喃-1-基)乙酰胺和n -(5-硝基-2-(5-苯基-1,3,4-恶二唑-2-基)萘[2,1-呋喃-1-基]乙酰胺及其衍生物的新合成、表征和抗菌活性

IF 0.5 Q4 EDUCATION & EDUCATIONAL RESEARCH

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI:10.31788/rjc.2023.1618088

K. M. Nagarsha, T. Sharanakumar, D. Ramesh, N. Kumar, M. N. Kumarswamy, D. Ramesh, K. P. Latha

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引用次数: 0

摘要

这部小说衍生品等naphtho-furan N - (5 bromo-2 - (5-phenyl-1 3 4-oxadiazol-2-yl)石脑油(2,1 b) furan-1 - yl)乙酰胺(8)、N - (5-bromo-2——(hydrazinecarbonyl)石脑油(2,1 b) furan-1-yl)乙酰胺(7),ethyl-1-acetamido-5——bromonaphtho (2, 1 b) furan-2-carboxylate(6)、N - (5-nitro-2——(5-phenyl-1 3 4-oxadiazol-2-yl)石脑油(2,1-bfuran-1 - yl)乙酰胺(5),N - (2 - (hydrazinecarbonyl) 5-nitronaphtho [2, 1 b] furan-1-yl)乙酰胺(4),ethyl-1-acetamido-5——nitrpnaphtho (2, 1 b) furan-2-carboxylate (3),由1-乙酰氨基萘[2,1-b]呋喃-2-羧酸乙酯和1-氨基萘[2,1-b]呋喃-2-羧酸乙酯制备。所有新合成的化合物均经质谱、核磁共振和红外光谱技术证实。这些化合物具有良好的抑菌活性和抗功能活性。

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NOVEL SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF N-(5BROMO-2-(5-PHENYL1,3,4-OXADIAZOL-2-YL)NAPHTHA[2,1-B]FURAN-1- YL)ACETAMIDE AND N-(5-NITRO-2-(5-PHENYL-1,3,4- OXADIAZOL-2-YL)NAPHTHA[2,1-BFURAN-1-YL]ACETAMIDE AND THEIR DERIVATIVES

The novel derivatives of naphtho-furan such N-(5bromo-2-(5-phenyl-1,3,4-oxadiazol-2-yl)naphtha[2,1-b]furan-1- yl)acetamide (8), N-(5-bromo-2-(hydrazinecarbonyl)naphtha[2,1-b]furan-1-yl]acetamide (7), ethyl-1-acetamido-5- bromonaphtho[2,1-b]furan-2-carboxylate (6), N-(5-nitro-2-(5-phenyl-1,3,4-oxadiazol-2-yl)naphtha[2,1-bfuran-1- yl]acetamide (5),N-(2-(hydrazinecarbonyl)-5-nitronaphtho[2,1-b]furan-1-yl)acetamide (4), ethyl-1-acetamido-5- nitrpnaphtho[2,1-b]furan-2-carboxylate (3), are prepared by ethyl-1-acetamidonaphtho[2,1-b]furan-2-carboxyate and ethyl 1-aminonaphtho[2,1-b]furan-2-carboxylate. All newly synthesized compounds were confirmed by Mass, NMR, and FTIR spectroscopic techniques. Those compounds were used for antimicrobial activity it exhibits good antibacterial and anti-functional activity.

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来源期刊

Rasayan Journal of Chemistry Energy-Energy (all)

CiteScore

1.90

自引率

0.00%

发文量

196

期刊介绍： RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.