营养和氧化应激在秀丽隐杆线虫衰老因子中的作用。

IF 2 4区医学 Q3 NUTRITION & DIETETICS

Journal of Clinical Biochemistry and Nutrition Pub Date : 2023-11-01 Epub Date: 2023-07-06 DOI:10.3164/jcbn.23-44

Kayo Yasuda, Masaki Miyazawa, Takamasa Ishii, Naoaki Ishii

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引用次数: 0

摘要

衰老的分子机制多年来一直是一个“黑盒子”，近年来才被阐明，而秀丽隐杆线虫作为衰老研究的模式动物，在其阐明中发挥了重要作用。从对秀丽隐杆线虫长寿相关突变基因的分析中，出现了许多以胰岛素/胰岛素样生长因子信号转导系统为核心的信号转导系统。这一信号转导系统受外界营养物质的影响较大，参与氧化应激的下游调控，被认为是导致衰老的主要原因之一。

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The role of nutrition and oxidative stress as aging factors in Caenorhabditis elegans.

The molecular mechanism of aging, which has been a "black box" for many years, has been elucidated in recent years, and the nematode C. elegans, which is a model animal for aging research, has played a major role in its elucidation. From the analysis of C. elegans longevity-related mutant genes, many signal transduction systems, with the insulin/insulin-like growth factor signal transduction system at the core, have emerged. It has become clear that this signal transduction system is greatly affected by external nutrients and is involved in the downstream regulation of oxidative stress, which is considered to be one of the main causes of aging.

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来源期刊

Journal of Clinical Biochemistry and Nutrition 医学-营养学

CiteScore

4.30

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Biochemistry and Nutrition (JCBN) is an international, interdisciplinary publication encompassing chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The Journal welcomes original contributions dealing with all aspects of clinical biochemistry and clinical nutrition including both in vitro and in vivo studies.