蕈样真菌病与牛皮癣鉴别诊断中的问题:临床与形态学特征的比较

Q4 Medicine

Clinical and Experimental Morphology Pub Date : 2022-01-01 DOI:10.31088/cem2022.11.3.73-80

V. Smolyannikova, A. Karamova, A. Vorontsova, L. F. Znamenskaya, M. Nefedova, K. M. Aulova

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引用次数: 1

摘要

蕈样真菌病是一种表皮性原发性皮肤t细胞淋巴瘤，由具有脑状核的中小型淋巴细胞组成。在某些情况下，皮肤t细胞淋巴瘤和慢性自身免疫性皮肤病(包括牛皮癣)的鉴别诊断可能存在重大挑战。我们分析了三例蕈样真菌病的临床病例，其中牛皮癣最初被诊断。用广泛的抗体(CD4 CD8、CD2、CD5、CD7、CD3)进行组织学和免疫组织化学研究，用PCR测定单克隆t淋巴细胞群。我们提出一种诊断蕈样真菌病的算法。关键词:蕈样真菌病，银屑病，形态学，免疫组织化学研究，诊断

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Problems in differential diagnosis of mycosis fungoides and psoriasis: comparison of clinical and morphological features

Mycosis fungoides is an epidermotropic primary cutaneous T-cell lymphoma, represented com-posed of small and medium-sized lymphocytes with cerebriform nuclei. Differential diagnosis of cutaneous T-cell lymphoma and chronic autoimmune dermatoses, including psoriasis, may present significant chal-lenges in some cases. We analyzed three clinical cases of mycosis fungoides, in which psoriasis was initially diagnosed. Histological and immunohistochemical studies with a wide panel of antibodies (CD4 CD8, CD2, CD5, CD7, CD3) were performed, and monoclonal T-lymphocyte populations were determined with PCR. We propose an algorithm for diagnosing mycosis fungoides. Keywords: mycosis fungoides, psoriasis, morphology, immunohistochemistrycal study, diagnosis

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来源期刊

Clinical and Experimental Morphology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

0.60

自引率

0.00%

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