探讨子宫自然杀伤细胞在妊娠中的意义

IF 1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Scienceasia Pub Date : 2023-01-01 DOI:10.2306/scienceasia1513-1874.2023.032

Tarique Hussain, G. Murtaza, Dildar Hussain Kalhoro, Muhammad Saleem Kalhoro, Muhammad Ismail Chughtai, Anjaleena Yaseen

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引用次数: 0

摘要

妊娠是一种涉及母胎交流的复杂生理现象。子宫自然杀伤细胞(uNK)在妊娠早期子宫内建立了深厚的淋巴细胞群。这些细胞与上皮外滋养细胞(EVT)和螺旋动脉密切相关，在螺旋动脉重塑、滋养细胞侵袭和胎盘发育中发挥重要作用。uNK细胞是细胞因子和生长因子的有效释放者;它与母胎界面的evt密切相关，在滋养细胞中发挥重要作用。目前，关于uNK细胞在正常妊娠和妊娠相关问题中的意义的解释研究有限。这篇综述文章阐明了uNK细胞在妊娠问题中的描述作用及其与其他免疫细胞成分的串扰。此外，我们还将讨论uNK细胞是否会有临床证据对妊娠构成威胁

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Exploiting the significance of uterine natural killer cells in pregnancy

: Pregnancy is a complex physiological phenomenon involving maternal-fetal communication. Uterine natural killer (uNK) cells established a profound lymphocyte population in the early pregnant uterus. These cells are closely linked with extravillous trophoblast (EVT) and spiral arteries and play a vital role in remodeling spiral arteries, trophoblast invasion and placental development. The uNK cells are the potent releasers of cytokines and growth factors; with close association to EVTs in the maternal-fetal interface, it drives an essential function in the trophoblast. At present, limited studies are available explaining the signiﬁcance of uNK cells in normal pregnancy and pregnancy-associated problems. This review article elucidates the descriptive role of uNK cells in pregnancy problems and their crosstalk with other immune cell components. Moreover, we will also discuss whether uNK cells become a threat to pregnancy with clinical evidence

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来源期刊

Scienceasia MULTIDISCIPLINARY SCIENCES-

CiteScore

1.70

自引率

33.30%

发文量

102

审稿时长

1 months

期刊介绍： ScienceAsia is a multidisciplinary journal publishing papers of high quality bimonthly, in printed and electronic versions, by the Science Society of Thailand under Royal Patronage and the National Research Council of Thailand. The journal publishes original research papers that provide novel findings and important contribution to broad area in science and mathematics. Areas covered include Biological Sciences and Biotechnology, Chemistry and Material Sciences, Environmental and Applied Sciences, and Mathematics and Physical Sciences. Manuscripts may report scientifically useful data, observations or model predictions, and/or provide a new scientific concept or a new explanation of published results. Submissions of materials of current scientific interest are highly welcome, provided that there is sufficient scientific merit. The journal will not accept manuscripts which have been published or are being considered for publication elsewhere, nor should manuscripts being considered by ScienceAsia be submitted to other journals. Submitted manuscripts must conform to the guidelines given in the Instructions for Authors