{"title":"卡马西平引起的严重皮肤不良反应与hla多态性的关系","authors":"S. Ratnaningrum","doi":"10.21776/UB.MNJ.2016.002.01.7","DOIUrl":null,"url":null,"abstract":"Carbamazepine as an antiepileptic drug that is used widely and was known can cause severe cutaneous adverse drug reactions like SJS-TEN. These adverse drug reactions is known to be associated with some specific HLA polymorphism in European populations (HLA-A*31: 01), China (HLA-A*31: 01; HLA-B*15: 02), Japan (HLA-A*31 : 01; HLA-B*15: 11), Korea HLA-A*31: 01; HLA-B*15: 02; HLA-B*15: 11), India (HLA-B*15: 02), Thailand (HLA-B*15: 02), and Malaysia (HLA-B*15: 02). Information related to certain HLA polymorphism is important to prevent adverse drug reaction but there is no sufficient data on the population of Indonesia.","PeriodicalId":31552,"journal":{"name":"Malang Neurology Journal","volume":"2 1","pages":"40-46"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ASSOCIATION BETWEEN CARBAMAZEPINE INDUCED SEVERE CUTANEOUS ADVERSE DRUG REACTION AND HLA POLIMORPHISMS\",\"authors\":\"S. Ratnaningrum\",\"doi\":\"10.21776/UB.MNJ.2016.002.01.7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Carbamazepine as an antiepileptic drug that is used widely and was known can cause severe cutaneous adverse drug reactions like SJS-TEN. These adverse drug reactions is known to be associated with some specific HLA polymorphism in European populations (HLA-A*31: 01), China (HLA-A*31: 01; HLA-B*15: 02), Japan (HLA-A*31 : 01; HLA-B*15: 11), Korea HLA-A*31: 01; HLA-B*15: 02; HLA-B*15: 11), India (HLA-B*15: 02), Thailand (HLA-B*15: 02), and Malaysia (HLA-B*15: 02). Information related to certain HLA polymorphism is important to prevent adverse drug reaction but there is no sufficient data on the population of Indonesia.\",\"PeriodicalId\":31552,\"journal\":{\"name\":\"Malang Neurology Journal\",\"volume\":\"2 1\",\"pages\":\"40-46\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Malang Neurology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21776/UB.MNJ.2016.002.01.7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Malang Neurology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21776/UB.MNJ.2016.002.01.7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
卡马西平作为一种广泛使用的抗癫痫药物，已知可引起严重的皮肤不良反应，如SJS-TEN。已知这些药物不良反应与欧洲人群(HLA- a * 31:01)、中国人群(HLA- a * 31:01;HLA-B* 15:02)，日本(HLA-A* 31:01;HLA-B* 15:11)，韩国HLA-A* 31:01;HLA-B * 15: 02;HLA-B* 15:11)、印度(HLA-B* 15:02)、泰国(HLA-B* 15:02)、马来西亚(HLA-B* 15:02)。与某些HLA多态性相关的信息对预防药物不良反应很重要，但在印度尼西亚人口中没有足够的数据。
ASSOCIATION BETWEEN CARBAMAZEPINE INDUCED SEVERE CUTANEOUS ADVERSE DRUG REACTION AND HLA POLIMORPHISMS
Carbamazepine as an antiepileptic drug that is used widely and was known can cause severe cutaneous adverse drug reactions like SJS-TEN. These adverse drug reactions is known to be associated with some specific HLA polymorphism in European populations (HLA-A*31: 01), China (HLA-A*31: 01; HLA-B*15: 02), Japan (HLA-A*31 : 01; HLA-B*15: 11), Korea HLA-A*31: 01; HLA-B*15: 02; HLA-B*15: 11), India (HLA-B*15: 02), Thailand (HLA-B*15: 02), and Malaysia (HLA-B*15: 02). Information related to certain HLA polymorphism is important to prevent adverse drug reaction but there is no sufficient data on the population of Indonesia.
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