植物源性产品治疗骨关节炎的疗效和安全性

L. Laslett, Xingzhong Jin, G. Jones
{"title":"植物源性产品治疗骨关节炎的疗效和安全性","authors":"L. Laslett, Xingzhong Jin, G. Jones","doi":"10.2147/BTAT.S33431","DOIUrl":null,"url":null,"abstract":"Background: \n \nPlant-derived therapies are traditionally used as medicines, but they have generally not been studied with the same rigor as pharmaceutical agents. This review summarizes the use of plant-derived products for osteoarthritis. Methods: \n \nSixty-three identified trials were summarized for pain, function, and safety outcomes using standardized mean differences (SMDs) and relative risks. Results: \n \nPlant-derived therapies are effective for treating pain compared to placebo, as assessed using visual analog scores and numerical rating scales (SMD, 1.08; 95% confidence interval [CI]: 0.72–1.44), or Western Ontario and McMaster University Osteoarthritis Index (WOMAC)/Knee injury and Osteoarthritis Outcome Score (KOOS) pain scales (SMD, 0.98; 95% CI: 0.62–1.35). Classes demonstrating overall efficacy in more than one trial for either visual analog scores or WOMAC pain included Boswellia serrata, capsaicin, and ginger; there was single-trial evidence of the efficacy of another nine agents. Plant-derived therapies have similar efficacy to an active comparator (SMD, 0.32; P = 0.08; -0.08; P = 0.14). Therapies are also effective for functional outcomes compared to placebo (SMD, 0.92; P =  Conclusion: \n \nPlant-derived therapies may be efficacious in treating osteoarthritic pain and functional limitations, and they appear to be safer than other active therapies. However, quality trials and long-term data are lacking, and the number of trials for each therapy is limited. Comparisons would be assisted by trial standardization.","PeriodicalId":91458,"journal":{"name":"Botanics : targets and therapy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/BTAT.S33431","citationCount":"3","resultStr":"{\"title\":\"Efficacy and safety of plant-derived products for the treatment of osteoarthritis\",\"authors\":\"L. Laslett, Xingzhong Jin, G. Jones\",\"doi\":\"10.2147/BTAT.S33431\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: \\n \\nPlant-derived therapies are traditionally used as medicines, but they have generally not been studied with the same rigor as pharmaceutical agents. This review summarizes the use of plant-derived products for osteoarthritis. Methods: \\n \\nSixty-three identified trials were summarized for pain, function, and safety outcomes using standardized mean differences (SMDs) and relative risks. Results: \\n \\nPlant-derived therapies are effective for treating pain compared to placebo, as assessed using visual analog scores and numerical rating scales (SMD, 1.08; 95% confidence interval [CI]: 0.72–1.44), or Western Ontario and McMaster University Osteoarthritis Index (WOMAC)/Knee injury and Osteoarthritis Outcome Score (KOOS) pain scales (SMD, 0.98; 95% CI: 0.62–1.35). Classes demonstrating overall efficacy in more than one trial for either visual analog scores or WOMAC pain included Boswellia serrata, capsaicin, and ginger; there was single-trial evidence of the efficacy of another nine agents. Plant-derived therapies have similar efficacy to an active comparator (SMD, 0.32; P = 0.08; -0.08; P = 0.14). Therapies are also effective for functional outcomes compared to placebo (SMD, 0.92; P =  Conclusion: \\n \\nPlant-derived therapies may be efficacious in treating osteoarthritic pain and functional limitations, and they appear to be safer than other active therapies. However, quality trials and long-term data are lacking, and the number of trials for each therapy is limited. Comparisons would be assisted by trial standardization.\",\"PeriodicalId\":91458,\"journal\":{\"name\":\"Botanics : targets and therapy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-12-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2147/BTAT.S33431\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Botanics : targets and therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/BTAT.S33431\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Botanics : targets and therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/BTAT.S33431","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

摘要

背景:植物源性疗法传统上被用作药物,但它们通常没有像药物制剂那样得到严格的研究。本文综述了植物源性产品治疗骨关节炎的应用。方法:采用标准化平均差异(SMDs)和相对风险对63项确定的试验的疼痛、功能和安全性结果进行总结。结果:与安慰剂相比,植物源性疗法在治疗疼痛方面是有效的,使用视觉模拟评分和数值评定量表(SMD, 1.08;95%可信区间[CI]: 0.72-1.44),或西安大略和麦克马斯特大学骨关节炎指数(WOMAC)/膝关节损伤和骨关节炎结局评分(oos)疼痛量表(SMD, 0.98;95% ci: 0.62-1.35)。在一个以上的试验中对视觉模拟评分或WOMAC疼痛表现出总体疗效的类别包括锯齿状乳香菌、辣椒素和生姜;还有另外九种药物的疗效的单次试验证据。植物源性疗法的疗效与活性比较物相似(SMD, 0.32;p = 0.08;-0.08;p = 0.14)。与安慰剂相比,治疗对功能结局也有效(SMD, 0.92;P =结论:植物源性疗法可能对治疗骨关节炎疼痛和功能限制有效,并且它们似乎比其他积极疗法更安全。然而,缺乏高质量的试验和长期数据,每种疗法的试验数量有限。试验标准化将有助于比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and safety of plant-derived products for the treatment of osteoarthritis
Background: Plant-derived therapies are traditionally used as medicines, but they have generally not been studied with the same rigor as pharmaceutical agents. This review summarizes the use of plant-derived products for osteoarthritis. Methods: Sixty-three identified trials were summarized for pain, function, and safety outcomes using standardized mean differences (SMDs) and relative risks. Results: Plant-derived therapies are effective for treating pain compared to placebo, as assessed using visual analog scores and numerical rating scales (SMD, 1.08; 95% confidence interval [CI]: 0.72–1.44), or Western Ontario and McMaster University Osteoarthritis Index (WOMAC)/Knee injury and Osteoarthritis Outcome Score (KOOS) pain scales (SMD, 0.98; 95% CI: 0.62–1.35). Classes demonstrating overall efficacy in more than one trial for either visual analog scores or WOMAC pain included Boswellia serrata, capsaicin, and ginger; there was single-trial evidence of the efficacy of another nine agents. Plant-derived therapies have similar efficacy to an active comparator (SMD, 0.32; P = 0.08; -0.08; P = 0.14). Therapies are also effective for functional outcomes compared to placebo (SMD, 0.92; P =  Conclusion: Plant-derived therapies may be efficacious in treating osteoarthritic pain and functional limitations, and they appear to be safer than other active therapies. However, quality trials and long-term data are lacking, and the number of trials for each therapy is limited. Comparisons would be assisted by trial standardization.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信