植物源性产品治疗骨关节炎的疗效和安全性

L. Laslett, Xingzhong Jin, G. Jones
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引用次数: 3

摘要

背景:植物源性疗法传统上被用作药物,但它们通常没有像药物制剂那样得到严格的研究。本文综述了植物源性产品治疗骨关节炎的应用。方法:采用标准化平均差异(SMDs)和相对风险对63项确定的试验的疼痛、功能和安全性结果进行总结。结果:与安慰剂相比,植物源性疗法在治疗疼痛方面是有效的,使用视觉模拟评分和数值评定量表(SMD, 1.08;95%可信区间[CI]: 0.72-1.44),或西安大略和麦克马斯特大学骨关节炎指数(WOMAC)/膝关节损伤和骨关节炎结局评分(oos)疼痛量表(SMD, 0.98;95% ci: 0.62-1.35)。在一个以上的试验中对视觉模拟评分或WOMAC疼痛表现出总体疗效的类别包括锯齿状乳香菌、辣椒素和生姜;还有另外九种药物的疗效的单次试验证据。植物源性疗法的疗效与活性比较物相似(SMD, 0.32;p = 0.08;-0.08;p = 0.14)。与安慰剂相比,治疗对功能结局也有效(SMD, 0.92;P =结论:植物源性疗法可能对治疗骨关节炎疼痛和功能限制有效,并且它们似乎比其他积极疗法更安全。然而,缺乏高质量的试验和长期数据,每种疗法的试验数量有限。试验标准化将有助于比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and safety of plant-derived products for the treatment of osteoarthritis
Background: Plant-derived therapies are traditionally used as medicines, but they have generally not been studied with the same rigor as pharmaceutical agents. This review summarizes the use of plant-derived products for osteoarthritis. Methods: Sixty-three identified trials were summarized for pain, function, and safety outcomes using standardized mean differences (SMDs) and relative risks. Results: Plant-derived therapies are effective for treating pain compared to placebo, as assessed using visual analog scores and numerical rating scales (SMD, 1.08; 95% confidence interval [CI]: 0.72–1.44), or Western Ontario and McMaster University Osteoarthritis Index (WOMAC)/Knee injury and Osteoarthritis Outcome Score (KOOS) pain scales (SMD, 0.98; 95% CI: 0.62–1.35). Classes demonstrating overall efficacy in more than one trial for either visual analog scores or WOMAC pain included Boswellia serrata, capsaicin, and ginger; there was single-trial evidence of the efficacy of another nine agents. Plant-derived therapies have similar efficacy to an active comparator (SMD, 0.32; P = 0.08; -0.08; P = 0.14). Therapies are also effective for functional outcomes compared to placebo (SMD, 0.92; P =  Conclusion: Plant-derived therapies may be efficacious in treating osteoarthritic pain and functional limitations, and they appear to be safer than other active therapies. However, quality trials and long-term data are lacking, and the number of trials for each therapy is limited. Comparisons would be assisted by trial standardization.
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