藤黄果皮对抗结核药物性大鼠肝损伤的抗氧化及肝保护作用

Vandana Panda, Hardik D. Ashar, A. Sharan
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引用次数: 9

摘要

研究了黄芩果皮水提物(GIE)对抗结核药物(ATD)所致大鼠肝损伤的保护作用。对ATD(异烟肼7.5 mg/kg、利福平10 mg/kg、吡嗪酰胺35 mg/kg)大鼠口服GIE (400 mg/kg、800 mg/kg)和参比药物Liv.52 (500 mg/kg) 29 d。GIE显著降低了ATD升高的天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶、胆红素和丙二醛水平,恢复了ATD缺失的谷胱甘肽(GSH)、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶水平。本研究结果提示,在ATD诱导的氧化损伤中,GIE的肝保护作用可能与其抗氧化活性有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antioxidant and hepatoprotective effects of Garcinia indica fruit rind in antitubercular drug-induced liver injury in rats
The protective effects of aqueous extracts of the fruit rind of Garcinia indica (GIE) in antitubercular drug (ATD)-induced liver injury were investigated in rats. GIE (400 mg/kg and 800 mg/kg) and the reference drug Liv.52 (500 mg/kg) were administered orally for 29 days to ATD (isoniazid 7.5 mg/kg, rifampicin 10 mg/kg, and pyrazinamide 35 mg/kg)-treated rats. GIE attenuated significantly the ATD-elevated levels of aspartate aminotransferase, alanine transaminase, alkaline phosphatase, bilirubin, and malondialdehyde and restored the ATD- depleted levels of glutathione (GSH), superoxide dismutase, catalase, GSH peroxidase, and GSH reductase. The present findings indicate that the hepatoprotective effect of GIE in ATD- induced oxidative damage may be due to its antioxidant activity.
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