乳腺癌胃和结肠转移:病例报告,文献回顾,以及可能的潜在机制

IF 3.3 4区 医学 Q2 ONCOLOGY
J. Carlos Villa Guzmán, J. Espinosa, R. Cervera, M. Delgado, R. Patón, Jm Cordero, García, J. Carlos, Villa Guzmán
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引用次数: 23

摘要

乳腺癌的胃肠道转移并不常见。我们报告一位58岁的女性,在几年前被诊断为小叶性乳腺癌,其复发是在胃和结肠粘膜。同时转移极为罕见。据我们所知,还没有报道过最初的双重矫形的病例。患者还表现为幽门螺杆菌引起的胃炎。浸润性小叶乳腺癌是最常见的特殊类型乳腺癌,它携带一些特定的分子改变,如e -钙粘蛋白的表达缺失。虽然转移的潜在机制尚不完全清楚,趋化因子和炎症事件似乎与这一过程有关。趋化因子与其受体之间的相互作用经常诱导细胞迁移。我们推测幽门螺杆菌、炎症细胞和趋化因子可能创造了一个吸引肿瘤细胞的有利环境。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms
Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin. Although underlying mechanisms of metastasization are not entirely known, chemokines as well as inflammatory events seem to be implicated in this process. Interaction between chemokines and their receptors frequently induces cell migration. We hypothesize that H. pylori, inflammatory cells, and chemokines may create a favorable environment attracting tumor cells.
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
40
审稿时长
16 weeks
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