舌癌患者3号染色体短臂上常见的等位基因丢失/不平衡。

IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Bulletin of Tokyo Dental College Pub Date : 2001-08-01 DOI:10.2209/TDCPUBLICATION.42.151

K. Arai, T. Shibahara, N. Yamamoto, T. Yakushiji, C. Tanaka, H. Noma

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引用次数: 14

摘要

常见的等位基因失衡包括3号染色体短臂杂合性缺失(LOH)和微卫星不稳定性(MSI)已在几种人类癌症中被发现。本研究旨在确定与舌鳞状细胞癌(SCC)相关的3p肿瘤抑制位点(或位点)。在16例舌SCC检测患者中，7例(44%)在16例信息丰富的病例中显示一个或多个位点的LOH。这16个肿瘤的缺失图谱显示了染色体臂上两个离散的、通常缺失的区域。我们的数据支持了促进舌鳞状细胞癌进展的肿瘤抑制基因位于3p24和3p25的观点。

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Frequent allelic loss/imbalance on the short arm of chromosome 3 in tongue cancer.

Frequent allelic imbalances including loss of heterozygosity (LOH) and microsatellite instability (MSI) on the short arm of chromosome 3 (3p) have been found in several types of human cancer. This study was designed to identify the tumor suppressor locus (or loci) on 3p associated with tongue squamous cell carcinoma (SCC). Among 16 patients with tongue SCC tested, 7 (44%) of 16 informative cases showed LOH at one or more loci. Deletion mapping of these 16 tumors revealed two discrete, commonly deleted regions on the chromosome arm. Our data support the notion that tumor suppressor gene(s) contributing to the progression of tongue squamous cell carcinoma reside on 3p24 and 3p25.

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来源期刊

Bulletin of Tokyo Dental College DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The bulletin of Tokyo Dental collegue is principally for the publication of original contributions to multidisciplinary research in dentistry.