n-6多不饱和脂肪酸对人体血液丙二醛-脱氧鸟苷加合物水平的影响

Q3 Medicine

Open Biomarkers Journal Pub Date : 2008-12-05 DOI:10.2174/1875318300801010028

S. A. Moore, E. Humphreys, Friesen, D. Shuker, S. Bingham

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引用次数: 3

摘要

研究了n-6多不饱和脂肪对血液中致突变DNA加合物丙二醛-脱氧鸟苷(M1dG)形成的作用，研究对象是摄入高饱和和多不饱和脂肪以及多不饱和脂肪加a-生育酚补充剂(每天400 IU)的男性志愿者(n = 13)。在第14天，饱和脂肪比多不饱和脂肪的加合物水平有显著差异，但这种影响在第20天消失了，这表明饮食脂肪变化对DNA损伤的影响有一个相对快速的调整。到第20天，a-生育酚显示出了一点益处。五名女性参与了PUFA研究，她们的平均加合物水平高于男性，但与激素状况无关。总的来说，PUFA对M1dG水平的有益影响有限，值得进一步研究。

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The Effect of n-6 Polyunsaturated Fatty Acid on Blood Levels of Malondialdehyde-Deoxyguanosine Adducts in Human Subjects~!2008-07-08~!2008-11-06~!2008-12-05~!

The role of n-6 polyunsaturated fats upon the formation of the mutagenic DNA adduct malondialdehyde- deoxyguanosine (M1dG) in blood was investigated in male volunteers (n = 13) who consumed diets high in saturated and polyunsaturated fats, and polyunsaturated fat plus a-tocopherol supplemention (400 IU per day). On day 14 there was a significant difference in adduct levels between diets with saturated fats giving higher levels than polyunsaturated fats but this effect had disappeared by day 20 indicating that there is a relatively rapid adjustment to the effects on DNA damage of changes in dietary fat. a-Tocopherol showed a small benefit by day 20. Five females participated in the PUFA study and had higher mean adduct levels than men but there was no correlation with hormonal status. Overall, PUFA had a lim- ited beneficial effect on M1dG levels that warrants further investigation.

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来源期刊

Open Biomarkers Journal Medicine-Medicine (miscellaneous)

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Open Biomarkers Journal is an Open Access online journal, which publishes original full-length, short research articles and reviews on biomarkers in clinical, medical and pharmaceutical research. The coverage includes biomarkers of disease, new biomarkers, exposure to drugs, genetic effects, and applications of biomarkers. The Open Biomarkers Journal, a peer reviewed journal, aims to provide the most complete and reliable source of information on current developments in the field. The emphasis will be on publishing quality articles rapidly and freely available to researchers worldwide.