羊奶及其制品中生物活性物质在预防神经退行性疾病中的作用

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES

Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice Pub Date : 2023-01-01 DOI:10.21521/mw.6796

Zuzanna Flis, E. Molik

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引用次数: 0

摘要

衰老是认知能力下降的主要危险因素，如阿尔茨海默病(AD)。羊奶可能在预防神经退行性疾病中发挥作用，因为它含有高含量的功能性肽，如乳铁蛋白。乳铁蛋白既可以作为活性治疗化合物，也可以作为药物纳米载体用于AD。与牛奶和羊奶相比，羊奶中共轭亚油酸(CLA)的异构体含量最高。c-9, t-11-CLA异构体主要通过减少脑组织中淀粉样蛋白-β聚集体的数量来减少AD发生的病理改变。羊奶还含有较高浓度的维生素D和b族维生素，它们具有神经保护作用。本文综述了目前关于羊奶及其制品的知识，特别关注其在预防神经退行性疾病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Role of bioactive substances in sheep's milk and its products in the prevention of neurodegenerative diseases

Aging is a major risk factor for cognitive decline, such as Alzheimer’s disease (AD). Sheep’s milk may play a role in the prevention of neurodegenerative diseases because of its high content of functional peptides, such as lactoferrin. Lactoferrin can be used in AD both as an active therapeutic compound and as a drug nanocarrier. Compared to cow’s and goat’s milks, sheep’s milk contains the highest content of isomers of conjugated linoleic acid (CLA). The c-9, t-11-CLA isomers reduce the pathological changes occurring in AD mainly by reducing the amount of amyloid-β aggregates in brain tissues. Sheep’s milk also contains higher concentrations of vitamin D and B-group vitamins, which have neuroprotective effects. This review summarizes the current knowledge on sheep’s milk and its products, with a special focus on its role in the prevention of neurodegenerative diseases.

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来源期刊

Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice VETERINARY SCIENCES-

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： "Medycyna Weterynaryjna" publishes various types of articles which are grouped in the following editorial categories: reviews, original studies, scientific and professional problems, the history of veterinary medicine, posthumous memoirs, as well as chronicles that briefly relate scientific advances and developments in the veterinary profession and medicine. The most important are the first two categories, which are published with short summaries in English. Moreover, from 2001 the editors of "Medycyna Weterynaryjna", bearing in mind market demands, has also started publishing entire works in English. Since 2008 the periodical has appeared in an electronic version. The following are available in this version: summaries of studies published from 1999 to 2005, full versions of all the studies published in the years 2006-2011 (in pdf files), and full versions of the English studies published in the current year (pdf). Only summaries of the remaining studies from the current year are available. In accordance with the principles accepted by the editors, the full versions of these texts will not be made available until next year. All articles are evaluated twice by leading Polish scientists and professionals before they are considered for publication. For years now "Medycyna Weterynaryjna" has maintained a high standard thanks to this system. The review articles are actually succinct monographs dealing with specific scientific and professional problems that are based on the most recent findings. Original works have a particular value, since they present research carried out in Polish and international scientific centers.