{"title":"社论-关于生长激素和胰岛素样生长因子及其在中枢神经系统中的作用的最新知识","authors":"F. Nyberg","doi":"10.2174/1874216501206010001","DOIUrl":null,"url":null,"abstract":"GH mediates most of its effects by releasing insulin-like growth factor-1 (IGF-1) through stimulation of GH receptors (GHR), in particular in the liver. Both GH and IGF-1 are shown to cross the blood-brain barrier (BBB) and affect specific targets for these hormones in the brain. The discovery of GH and IGF-1 receptors in the CNS and their distribution in brain areas associated with the functional anatomy of behavioral effects induced by activation of the somatotrophic axis (GH/IGF-1 axis) has brought up new aspects on the mechanisms underlying beneficial effects seen for the two hormones.","PeriodicalId":88751,"journal":{"name":"The open endocrinology journal","volume":"6 1","pages":"1-2"},"PeriodicalIF":0.0000,"publicationDate":"2012-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Editorial - Current Knowledge on Growth Hormone and Insulin-Like GrowthFactors and their Role in the Central Nervous System\",\"authors\":\"F. Nyberg\",\"doi\":\"10.2174/1874216501206010001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"GH mediates most of its effects by releasing insulin-like growth factor-1 (IGF-1) through stimulation of GH receptors (GHR), in particular in the liver. Both GH and IGF-1 are shown to cross the blood-brain barrier (BBB) and affect specific targets for these hormones in the brain. The discovery of GH and IGF-1 receptors in the CNS and their distribution in brain areas associated with the functional anatomy of behavioral effects induced by activation of the somatotrophic axis (GH/IGF-1 axis) has brought up new aspects on the mechanisms underlying beneficial effects seen for the two hormones.\",\"PeriodicalId\":88751,\"journal\":{\"name\":\"The open endocrinology journal\",\"volume\":\"6 1\",\"pages\":\"1-2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The open endocrinology journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874216501206010001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open endocrinology journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874216501206010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Editorial - Current Knowledge on Growth Hormone and Insulin-Like GrowthFactors and their Role in the Central Nervous System
GH mediates most of its effects by releasing insulin-like growth factor-1 (IGF-1) through stimulation of GH receptors (GHR), in particular in the liver. Both GH and IGF-1 are shown to cross the blood-brain barrier (BBB) and affect specific targets for these hormones in the brain. The discovery of GH and IGF-1 receptors in the CNS and their distribution in brain areas associated with the functional anatomy of behavioral effects induced by activation of the somatotrophic axis (GH/IGF-1 axis) has brought up new aspects on the mechanisms underlying beneficial effects seen for the two hormones.
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