{"title":"1型糖尿病与2型糖尿病/代谢综合征:疫苗引起的免疫谱紊乱的两个极端","authors":"J. Classen","doi":"10.2174/1874216500802010009","DOIUrl":null,"url":null,"abstract":"There is an epidemic in children of type 2 diabetes and metabolic syndrome including individual diseases that form the components of metabolic syndrome. The epidemic resembles the epidemic of type 1 diabetes in children which has been linked to immunization. The epidemic of obesity in US children has a statistically significant positive correlation with the number of vaccine doses recommended. There is a similar trend with both hypertension and metabolic syndrome. The incidence of type 2 diabetes in Japanese children decreased significantly following the discontinuation of the BCG vaccine, a vaccine which is associated with an increased risk of type 1 diabetes. This paper describes two aberrant re- sponses to immunization. At one extreme immunization leads to progressive autoimmune diseases including type 1 diabe- tes. A second response to immunization, and an opposite extreme to autoimmunity, is for the body to suppress the im- mune system through increased cortisol activity and other counter measures leading to type 2 diabetes and metabolic syn- drome. Some vaccine recipients may have a mixed response, falling between the extremes, such as an incomplete auto- immune disorder or an intermittent autoimmune disorder. The propensity to develop a particular response relates to race. Japanese children produce large amounts of cortisol following immunization and have lower risk of type 1 diabetes but higher risk of type 2 diabetes than White children. Analysis using Austin Bradford-Hill criteria for causation support a causal relation between immunization and metabolic syndrome. Additional studies are needed to further characterize this risk.","PeriodicalId":88751,"journal":{"name":"The open endocrinology journal","volume":"2 1","pages":"9-15"},"PeriodicalIF":0.0000,"publicationDate":"2008-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Type 1 Diabetes Versus Type 2 Diabetes/Metabolic Syndrome, Opposite Extremes of an Immune Spectrum Disorder Induced by Vaccines\",\"authors\":\"J. Classen\",\"doi\":\"10.2174/1874216500802010009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"There is an epidemic in children of type 2 diabetes and metabolic syndrome including individual diseases that form the components of metabolic syndrome. The epidemic resembles the epidemic of type 1 diabetes in children which has been linked to immunization. The epidemic of obesity in US children has a statistically significant positive correlation with the number of vaccine doses recommended. There is a similar trend with both hypertension and metabolic syndrome. The incidence of type 2 diabetes in Japanese children decreased significantly following the discontinuation of the BCG vaccine, a vaccine which is associated with an increased risk of type 1 diabetes. This paper describes two aberrant re- sponses to immunization. At one extreme immunization leads to progressive autoimmune diseases including type 1 diabe- tes. A second response to immunization, and an opposite extreme to autoimmunity, is for the body to suppress the im- mune system through increased cortisol activity and other counter measures leading to type 2 diabetes and metabolic syn- drome. Some vaccine recipients may have a mixed response, falling between the extremes, such as an incomplete auto- immune disorder or an intermittent autoimmune disorder. The propensity to develop a particular response relates to race. Japanese children produce large amounts of cortisol following immunization and have lower risk of type 1 diabetes but higher risk of type 2 diabetes than White children. Analysis using Austin Bradford-Hill criteria for causation support a causal relation between immunization and metabolic syndrome. Additional studies are needed to further characterize this risk.\",\"PeriodicalId\":88751,\"journal\":{\"name\":\"The open endocrinology journal\",\"volume\":\"2 1\",\"pages\":\"9-15\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The open endocrinology journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874216500802010009\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open endocrinology journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874216500802010009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Type 1 Diabetes Versus Type 2 Diabetes/Metabolic Syndrome, Opposite Extremes of an Immune Spectrum Disorder Induced by Vaccines
There is an epidemic in children of type 2 diabetes and metabolic syndrome including individual diseases that form the components of metabolic syndrome. The epidemic resembles the epidemic of type 1 diabetes in children which has been linked to immunization. The epidemic of obesity in US children has a statistically significant positive correlation with the number of vaccine doses recommended. There is a similar trend with both hypertension and metabolic syndrome. The incidence of type 2 diabetes in Japanese children decreased significantly following the discontinuation of the BCG vaccine, a vaccine which is associated with an increased risk of type 1 diabetes. This paper describes two aberrant re- sponses to immunization. At one extreme immunization leads to progressive autoimmune diseases including type 1 diabe- tes. A second response to immunization, and an opposite extreme to autoimmunity, is for the body to suppress the im- mune system through increased cortisol activity and other counter measures leading to type 2 diabetes and metabolic syn- drome. Some vaccine recipients may have a mixed response, falling between the extremes, such as an incomplete auto- immune disorder or an intermittent autoimmune disorder. The propensity to develop a particular response relates to race. Japanese children produce large amounts of cortisol following immunization and have lower risk of type 1 diabetes but higher risk of type 2 diabetes than White children. Analysis using Austin Bradford-Hill criteria for causation support a causal relation between immunization and metabolic syndrome. Additional studies are needed to further characterize this risk.