1型糖尿病与2型糖尿病/代谢综合征:疫苗引起的免疫谱紊乱的两个极端

J. Classen
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引用次数: 6

摘要

儿童中流行2型糖尿病和代谢综合征,包括构成代谢综合征组成部分的个别疾病。这种流行病类似于儿童1型糖尿病的流行,后者与免疫接种有关。美国儿童肥胖的流行与推荐的疫苗剂量有统计学上显著的正相关。高血压和代谢综合征也有类似的趋势。日本儿童2型糖尿病的发病率在卡介苗(一种与1型糖尿病风险增加相关的疫苗)停止接种后显著下降。本文描述了对免疫的两种异常反应。一种极端情况是免疫导致进行性自身免疫性疾病,包括1型糖尿病。免疫的第二种反应,与自身免疫相反,是身体通过增加皮质醇活性和其他对抗措施来抑制免疫系统,导致2型糖尿病和代谢综合征。一些疫苗接种者可能有混合反应,介于两种极端之间,如不完全自身免疫紊乱或间歇性自身免疫紊乱。产生特定反应的倾向与种族有关。日本儿童在免疫接种后产生大量的皮质醇,与白人儿童相比,日本儿童患1型糖尿病的风险较低,但患2型糖尿病的风险较高。使用Austin Bradford-Hill标准进行因果关系分析,支持免疫和代谢综合征之间的因果关系。需要进一步的研究来进一步确定这种风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Type 1 Diabetes Versus Type 2 Diabetes/Metabolic Syndrome, Opposite Extremes of an Immune Spectrum Disorder Induced by Vaccines
There is an epidemic in children of type 2 diabetes and metabolic syndrome including individual diseases that form the components of metabolic syndrome. The epidemic resembles the epidemic of type 1 diabetes in children which has been linked to immunization. The epidemic of obesity in US children has a statistically significant positive correlation with the number of vaccine doses recommended. There is a similar trend with both hypertension and metabolic syndrome. The incidence of type 2 diabetes in Japanese children decreased significantly following the discontinuation of the BCG vaccine, a vaccine which is associated with an increased risk of type 1 diabetes. This paper describes two aberrant re- sponses to immunization. At one extreme immunization leads to progressive autoimmune diseases including type 1 diabe- tes. A second response to immunization, and an opposite extreme to autoimmunity, is for the body to suppress the im- mune system through increased cortisol activity and other counter measures leading to type 2 diabetes and metabolic syn- drome. Some vaccine recipients may have a mixed response, falling between the extremes, such as an incomplete auto- immune disorder or an intermittent autoimmune disorder. The propensity to develop a particular response relates to race. Japanese children produce large amounts of cortisol following immunization and have lower risk of type 1 diabetes but higher risk of type 2 diabetes than White children. Analysis using Austin Bradford-Hill criteria for causation support a causal relation between immunization and metabolic syndrome. Additional studies are needed to further characterize this risk.
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