2型糖尿病微血管并发症的抗氧化酶和脂质过氧化状况

M. Kumawat, M. Pahwa, Veena Gahlaut, Neelima Singh
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引用次数: 48

摘要

在糖尿病患者中,持续高血糖被认为是氧自由基产生增加的原因之一。高血糖可诱发氧化应激,成为糖尿病并发症的主要诱因。本研究旨在了解脂质过氧化产物丙二醛(MDA)和抗氧化酶(AOEs)如谷胱甘肽过氧化物酶(GPx)、谷胱甘肽还原酶(GR)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)和还原性谷胱甘肽(GSH)的状况,为糖尿病各种并发症的风险评估提供依据。该研究包括300名受试者(50-70岁),其中150名患者是非胰岛素依赖型糖尿病(NIDDM)伴微血管并发症,150名年龄匹配的健康对照。测定各组空腹血糖(FBS)、还原性谷胱甘肽(GSH)、GPx、GR、CAT、SOD、MDA水平。结果FBS、CAT、MDA显著升高(p< 0.001), GSH、GPx、GR、SOD显著降低(p< 0.001)。提示抗氧化状态和MDA的改变可能有助于预测糖尿病各种微血管并发症的发生风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Status of Antioxidant Enzymes and Lipid Peroxidation in Type 2 Diabetes Mellitus with Micro Vascular Complications
In diabetic patients, persistence of hyperglycemia has been reported as a cause of increased production of oxy- gen free radicals. Hyperglycemia could induce oxidative stress and become the main factor for predisposing the complica- tions in diabetes. The study is being aimed to find out the status of lipid peroxidation product i.e. malondialdehyde (MDA) and antioxidant enzymes (AOEs) such as glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), superoxide dismutase (SOD) and reduced glutathione (GSH) which might be helpful in risk assessment of various complications of diabetes mellitus. The study included 300 subjects (50-70yrs) out of which 150 patients were non insulin dependent diabetes mellitus (NIDDM) with micro vascular complications and 150 age matched healthy controls. The status of fasting blood sugar (FBS), reduced glutathione (GSH), GPx, GR, CAT, SOD and MDA were determined. Our results showed significant increase (p< 0.001) in FBS, CAT and MDA while GSH, GPx, GR and SOD were found decreased significantly (p< 0.001). The data suggest that alteration in antioxidant status and MDA may help to predict the risk of various micro vascular complications of diabetes mellitus.
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