m-MSC:基于分子通讯的细胞因子风暴MSC控制治疗分析

IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC
Saswati Pal;Sudip Misra;Nabiul Islam
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引用次数: 0

摘要

COVID-19诱导的细胞因子风暴是由于细胞因子分子的过度分泌而形成的,会导致多器官损伤,随后导致COVID-19]患者死亡。间充质干细胞(MSCs)被认为是对抗细胞因子风暴的超炎症反应的细胞疫苗。然而,由于复杂的血管网络和不同的个体免疫反应,确定在一定时间内输注MSC的所需剂量是具有挑战性的。在这项工作中,我们提出了一个基于分子通讯的系统来模拟MSC对细胞因子风暴的传播、繁殖和免疫调节反应。所提出的分析模型为系统的行为提供了有价值的见解,并可作为进一步基于实验的研究的框架,以估计MSC的所需剂量。我们分析了MSCs传播过程中血管通道的不同形状和几何形状。我们观察到,较高的剪切应力阻碍了MSC信号的传播,而较低的剪应力诱导了沿着通道的传播。模拟结果显示MSC信号在施用MSC后的四个模拟日内达到峰值。此外,结果表明,需要每隔几天重复MSC输注,以维持对细胞因子风暴的长期免疫调节作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
m-MSC: Molecular Communication-Based Analysis for Controlled MSC Treatment of Cytokine Storm
COVID-19-induced cytokine storm, which is formed due to the excessive secretion of cytokine molecules, causes multi-organ damage and subsequently, the death of COVID-19 patients. Mesenchymal Stem Cells (MSCs) are regarded as cellular vaccines to combat the hyper-inflammatory response to cytokine storms. However, determining the required dose of MSCs to be infused within a certain time period is challenging due to the complex vascular networks and varying individual immune responses. In this work, we propose a molecular communication-based system to model the transmission, propagation, and immuno-modulatory response of MSCs to the cytokine storm. The proposed analytical model provides valuable insights into the behavior of the system and can be used as a framework for further experimental-based studies to estimate the required dose of MSCs. We analyze the varying shapes and geometries of the vascular channel on the propagation of the MSCs. We observe that the higher shear stress hinders MSC signal propagation, while lower shear stress induces propagation along the channel. Simulation results show that the MSC signal peaks in four simulation days upon administering the MSCs. Further, the results reveal that repeating the MSC infusion on alternate days is required to maintain a prolonged immuno-modulating effect on the cytokine storm.
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来源期刊
CiteScore
3.90
自引率
13.60%
发文量
23
期刊介绍: As a result of recent advances in MEMS/NEMS and systems biology, as well as the emergence of synthetic bacteria and lab/process-on-a-chip techniques, it is now possible to design chemical “circuits”, custom organisms, micro/nanoscale swarms of devices, and a host of other new systems. This success opens up a new frontier for interdisciplinary communications techniques using chemistry, biology, and other principles that have not been considered in the communications literature. The IEEE Transactions on Molecular, Biological, and Multi-Scale Communications (T-MBMSC) is devoted to the principles, design, and analysis of communication systems that use physics beyond classical electromagnetism. This includes molecular, quantum, and other physical, chemical and biological techniques; as well as new communication techniques at small scales or across multiple scales (e.g., nano to micro to macro; note that strictly nanoscale systems, 1-100 nm, are outside the scope of this journal). Original research articles on one or more of the following topics are within scope: mathematical modeling, information/communication and network theoretic analysis, standardization and industrial applications, and analytical or experimental studies on communication processes or networks in biology. Contributions on related topics may also be considered for publication. Contributions from researchers outside the IEEE’s typical audience are encouraged.
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