{"title":"用磁粉成像检测器在体测量非人类灵长类动物脑SPIO浓度","authors":"Hui Hui;Jiaojiao Liu;Hui Zhang;Jing Zhong;Jie He;Bo Zhang;Haoran Zhang;Qin Li;Hongjun Li;Jie Tian","doi":"10.1109/LMAG.2023.3281933","DOIUrl":null,"url":null,"abstract":"The purpose of this study is to develop a magnetic particle imaging (MPI) technique to directly measure time-varied cerebral superparamagnetic iron oxide nanoparticle (SPIO) concentration in rhesus macaques. A hand-held MPI detector was developed to monitor MPI signal changes at the third harmonics of the drive frequency in resting-state nonhuman primates. Phantom experiments were first performed to determine the sensitivity limits of the detector as a function of distance from the detector and SPIO concentration. The measured sensitivity profile was then used to reveal the most sensitive region of the detector. MPI detection was continuously performed to monitor MPI signal changes after two bolus injections of SPIOs in the rhesus macaque. We successfully developed a hand-held MPI to detect cerebral SPIO concentration changes in a living nonhuman primate. The detection limit of the MPI detector is about 125 ng iron. We reported on the \n<italic>in vivo</i>\n measurement of cerebral SPIO concentration changes in rhesus macaque using a hand-held MPI detector. \n<italic>In vivo</i>\n experiments showed the feasibility of the detector to sensitively measure MPI signals in a nonhuman primate brain.","PeriodicalId":13040,"journal":{"name":"IEEE Magnetics Letters","volume":"14 ","pages":"1-5"},"PeriodicalIF":1.1000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/iel7/5165412/10018138/10141661.pdf","citationCount":"1","resultStr":"{\"title\":\"In Vivo Measurement of Cerebral SPIO Concentration in Nonhuman Primate Using Magnetic Particle Imaging Detector\",\"authors\":\"Hui Hui;Jiaojiao Liu;Hui Zhang;Jing Zhong;Jie He;Bo Zhang;Haoran Zhang;Qin Li;Hongjun Li;Jie Tian\",\"doi\":\"10.1109/LMAG.2023.3281933\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The purpose of this study is to develop a magnetic particle imaging (MPI) technique to directly measure time-varied cerebral superparamagnetic iron oxide nanoparticle (SPIO) concentration in rhesus macaques. A hand-held MPI detector was developed to monitor MPI signal changes at the third harmonics of the drive frequency in resting-state nonhuman primates. Phantom experiments were first performed to determine the sensitivity limits of the detector as a function of distance from the detector and SPIO concentration. The measured sensitivity profile was then used to reveal the most sensitive region of the detector. MPI detection was continuously performed to monitor MPI signal changes after two bolus injections of SPIOs in the rhesus macaque. We successfully developed a hand-held MPI to detect cerebral SPIO concentration changes in a living nonhuman primate. The detection limit of the MPI detector is about 125 ng iron. We reported on the \\n<italic>in vivo</i>\\n measurement of cerebral SPIO concentration changes in rhesus macaque using a hand-held MPI detector. \\n<italic>In vivo</i>\\n experiments showed the feasibility of the detector to sensitively measure MPI signals in a nonhuman primate brain.\",\"PeriodicalId\":13040,\"journal\":{\"name\":\"IEEE Magnetics Letters\",\"volume\":\"14 \",\"pages\":\"1-5\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ieeexplore.ieee.org/iel7/5165412/10018138/10141661.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IEEE Magnetics Letters\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://ieeexplore.ieee.org/document/10141661/\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Magnetics Letters","FirstCategoryId":"101","ListUrlMain":"https://ieeexplore.ieee.org/document/10141661/","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
In Vivo Measurement of Cerebral SPIO Concentration in Nonhuman Primate Using Magnetic Particle Imaging Detector
The purpose of this study is to develop a magnetic particle imaging (MPI) technique to directly measure time-varied cerebral superparamagnetic iron oxide nanoparticle (SPIO) concentration in rhesus macaques. A hand-held MPI detector was developed to monitor MPI signal changes at the third harmonics of the drive frequency in resting-state nonhuman primates. Phantom experiments were first performed to determine the sensitivity limits of the detector as a function of distance from the detector and SPIO concentration. The measured sensitivity profile was then used to reveal the most sensitive region of the detector. MPI detection was continuously performed to monitor MPI signal changes after two bolus injections of SPIOs in the rhesus macaque. We successfully developed a hand-held MPI to detect cerebral SPIO concentration changes in a living nonhuman primate. The detection limit of the MPI detector is about 125 ng iron. We reported on the
in vivo
measurement of cerebral SPIO concentration changes in rhesus macaque using a hand-held MPI detector.
In vivo
experiments showed the feasibility of the detector to sensitively measure MPI signals in a nonhuman primate brain.
期刊介绍:
IEEE Magnetics Letters is a peer-reviewed, archival journal covering the physics and engineering of magnetism, magnetic materials, applied magnetics, design and application of magnetic devices, bio-magnetics, magneto-electronics, and spin electronics. IEEE Magnetics Letters publishes short, scholarly articles of substantial current interest.
IEEE Magnetics Letters is a hybrid Open Access (OA) journal. For a fee, authors have the option making their articles freely available to all, including non-subscribers. OA articles are identified as Open Access.