脂肪酸结合蛋白对新生儿坏死性小肠结肠炎的诊断价值

Q3 Medicine

Voprosy Prakticheskoi Pediatrii Pub Date : 2022-01-01 DOI:10.20953/1817-7646-2022-4-13-16

L. V. Kim, V. Zhelev, G.V. Slizovsky

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引用次数: 0

摘要

目标。探讨脂肪酸结合蛋白(I-FABP)在早产儿坏死性小肠结肠炎(NEC)中的诊断价值。患者和方法。对38名早产儿进行了前瞻性研究。孩子们被分成两组。ⅰ组NEC患儿18例，对照组ⅱ早产儿20例。患者接受临床和实验室检查，腹腔x线摄影和血清I-FABP水平测定。结果。在研究的所有阶段:出生时、肠内喂养开始时和NEC诊断时，主组儿童的血清I-FABP水平均显著升高(p < 0.001)。I-FABP水平与NEC分期之间存在相关性。结论。连续测定血清I-FABP水平可作为NEC早期诊断和疾病严重程度预测的有用指标。关键词:坏死性小肠结肠炎，早期诊断，生物标志物，早产，新生儿

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Diagnostic value of fatty acid-binding protein in newborns with necrotizing enterocolitis

Objective. To determine the diagnostic value of fatty acid binding protein (I-FABP) in premature infants with necrotizing enterocolitis (NEC). Patients and methods. A prospective study was conducted that included 38 premature infants. The children were divided into 2 groups. Group I included 18 children with NEC, 20 premature infants were included in control group II. Patients underwent clinical and laboratory examination, radiography of the abdominal cavity and measurement of the level of I-FABP in serum. Results. Serum I-FABP levels were significantly higher in children from the main group at all stages of the study: at birth, at the beginning of enteral feeding and at the time of diagnosis of NEC (p < 0,001). There is a correlation between the I-FABP level and the NEC stage. Conclusion. Sequential measurements of serum I-FABP levels can be a useful marker for early diagnosis and prediction of disease severity in NEC. Key words: necrotizing enterocolitis, early diagnosis, biomarker, premature, newborns

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来源期刊

Voprosy Prakticheskoi Pediatrii Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.20

自引率

0.00%

发文量