我们对癫痫发生和癫痫机制的看法如何改变?系统癫痫的概念]。

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY

Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2022-03-31 DOI:10.18071/isz.75.0079

P. Halász, A. Szűcs

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引用次数: 0

摘要

背景与目的探讨与系统性癫痫概念密切相关的癫痫发生途径。方法观察陈述性记忆系统、睡眠/觉醒双系统、外围神经网络和损伤后癫痫的癫痫转化方式，认为这是癫痫转化的一般模式。结果在上述系统中，癫痫发生的机制相似，均表现为可塑性的增强和脱轨以及与睡眠相关的突触稳态。这凸显了非快速眼动睡眠在癫痫发作中的核心作用。结论我们试图描述系统性癫痫的概念，并提出一种共同的癫痫发生机制。

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[How our view of epileptogenesis and mechanism of epilepsy changes? The system epilepsies' concept].

Background and purpose To examine the ways of epileptogenesis closely linked to the system epilepsies' concept. Methods We follow the ways of epileptic transformation in the declarative memory-system, in the sleep/arousal twin-systems, in the perisylvian neuronal network and in postinjury epilepsy, which we consider a general model of the epileptic transformation. Results In the presented systems, epileptogenesis shares a similar mechanism in the form of augmentation and derailment of plasticity and sleep-related synaptic homeo-stasis. This highlights the central role of NREM sleep in those epilepsies. Conclusion We try to characterize the concept of system epilepsies and suggest a shared mechanism of epileptogenesis.

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来源期刊

Ideggyogyaszati Szemle-Clinical Neuroscience CLINICAL NEUROLOGY-NEUROSCIENCES

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Clinical Neuroscience (Ideggyógyászati Szemle) is to provide a forum for the exchange of clinical and scientific information for a multidisciplinary community. The Clinical Neuroscience will be of primary interest to neurologists, neurosurgeons, psychiatrist and clinical specialized psycholigists, neuroradiologists and clinical neurophysiologists, but original works in basic or computer science, epidemiology, pharmacology, etc., relating to the clinical practice with involvement of the central nervous system are also welcome.