P. Suwalski, Michele Violano, Melina Müller, D. Patriki, C. Thibeault, C. Quedenau, Xiaomin Wang, Zehra Karadeniz, J. Saccomanno, Jan-Moritz Doehn, R. Hübner, B. Hinzmann, H. Beer, B. Wiggli, Sandra Siemann, N. Suttorp, M. Witzenrath, S. Hippenstiel, C. Skurk, W. Poller, L. Sander, F. Kurth, Tatiana Borodina, T. Guettouche, U. Landmesser, B. Heidecker
{"title":"男性HLA-C*04:01携带者在COVID-19中心脏损伤的风险增加","authors":"P. Suwalski, Michele Violano, Melina Müller, D. Patriki, C. Thibeault, C. Quedenau, Xiaomin Wang, Zehra Karadeniz, J. Saccomanno, Jan-Moritz Doehn, R. Hübner, B. Hinzmann, H. Beer, B. Wiggli, Sandra Siemann, N. Suttorp, M. Witzenrath, S. Hippenstiel, C. Skurk, W. Poller, L. Sander, F. Kurth, Tatiana Borodina, T. Guettouche, U. Landmesser, B. Heidecker","doi":"10.20517/jca.2022.19","DOIUrl":null,"url":null,"abstract":"Identification of factors that lead to the severe clinical course of COVID-19 is crucial for timely allocation of resources. The purpose of this study was to evaluate possible sex differences in cardiac injury associated with HLA-C*04:01. High sensitivity troponin T on admission (hs-TnTa) and maximum high sensitivity troponin T (hs-TnTmax) were used to assess for cardiac injury in patients with COVID-19 (n = 435). We tested for the association of elevated hs-TnT with HLA-C* 04:01 and evaluated for potential sex-specific differences. An association between hs-TnTa and the severity of clinical course was identified. In addition, our study revealed that hs-TnTmax was higher in men who were carriers of HLA-C*04:01 compared to men without the risk allele. Male carriers of HLA-C*04:01 with COVID-19 developed higher hs-TnTmax, suggesting a larger extent of cardiac injury. This association suggests the presence of different pathomechanisms in COVID-19 based on sex.","PeriodicalId":75051,"journal":{"name":"The journal of cardiovascular aging","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Male carriers of HLA-C*04:01 have increased risk of cardiac injury in COVID-19\",\"authors\":\"P. Suwalski, Michele Violano, Melina Müller, D. Patriki, C. Thibeault, C. Quedenau, Xiaomin Wang, Zehra Karadeniz, J. Saccomanno, Jan-Moritz Doehn, R. Hübner, B. Hinzmann, H. Beer, B. Wiggli, Sandra Siemann, N. Suttorp, M. Witzenrath, S. Hippenstiel, C. Skurk, W. Poller, L. Sander, F. Kurth, Tatiana Borodina, T. Guettouche, U. Landmesser, B. Heidecker\",\"doi\":\"10.20517/jca.2022.19\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Identification of factors that lead to the severe clinical course of COVID-19 is crucial for timely allocation of resources. The purpose of this study was to evaluate possible sex differences in cardiac injury associated with HLA-C*04:01. High sensitivity troponin T on admission (hs-TnTa) and maximum high sensitivity troponin T (hs-TnTmax) were used to assess for cardiac injury in patients with COVID-19 (n = 435). We tested for the association of elevated hs-TnT with HLA-C* 04:01 and evaluated for potential sex-specific differences. An association between hs-TnTa and the severity of clinical course was identified. In addition, our study revealed that hs-TnTmax was higher in men who were carriers of HLA-C*04:01 compared to men without the risk allele. Male carriers of HLA-C*04:01 with COVID-19 developed higher hs-TnTmax, suggesting a larger extent of cardiac injury. This association suggests the presence of different pathomechanisms in COVID-19 based on sex.\",\"PeriodicalId\":75051,\"journal\":{\"name\":\"The journal of cardiovascular aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The journal of cardiovascular aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20517/jca.2022.19\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The journal of cardiovascular aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20517/jca.2022.19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Male carriers of HLA-C*04:01 have increased risk of cardiac injury in COVID-19
Identification of factors that lead to the severe clinical course of COVID-19 is crucial for timely allocation of resources. The purpose of this study was to evaluate possible sex differences in cardiac injury associated with HLA-C*04:01. High sensitivity troponin T on admission (hs-TnTa) and maximum high sensitivity troponin T (hs-TnTmax) were used to assess for cardiac injury in patients with COVID-19 (n = 435). We tested for the association of elevated hs-TnT with HLA-C* 04:01 and evaluated for potential sex-specific differences. An association between hs-TnTa and the severity of clinical course was identified. In addition, our study revealed that hs-TnTmax was higher in men who were carriers of HLA-C*04:01 compared to men without the risk allele. Male carriers of HLA-C*04:01 with COVID-19 developed higher hs-TnTmax, suggesting a larger extent of cardiac injury. This association suggests the presence of different pathomechanisms in COVID-19 based on sex.
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