{"title":"接种疫苗与未接种疫苗儿童的健康影响,包括母乳喂养状况和出生类型","authors":"Brian S. Hooker, Neil Z. Miller","doi":"10.15761/jts.1000459","DOIUrl":null,"url":null,"abstract":"Using survey data from respondents associated with three medical practices in the US, vaccinated children were compared to unvaccinated children for the incidence of severe allergies, autism, gastrointestinal disorders, asthma, ADHD, and chronic ear infections. All diagnoses were based on parental reporting with chart review for confirmation of diagnoses. Cases were stratified with non-cases based on year of birth and sex, and compared using a logistic regression model which also accounted for breastfeeding status and type of birth (vaginal versus cesarean section). Vaccinated children were significantly more likely than unvaccinated children to be diagnosed with severe allergies (OR = 4.31, 95% CI 1.67 - 11.1), autism (OR = 5.03, 95% CI 1.64 - 15.5), gastrointestinal disorders (OR = 13.8, 95% CI 5.85 - 32.5), asthma (OR = 17.6, 95% CI 6.94 - 44.4), ADHD (OR = 20.8, 95% CI 4.74 - 91.2), and chronic ear infections (OR = 27.8, 95% CI 9.56 - 80.8). Vaccinated children were less likely to be diagnosed with chickenpox (OR = 0.10, 95% CI 0.029","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Health effects in vaccinated versus unvaccinated children, with covariates for breastfeeding status and type of birth\",\"authors\":\"Brian S. Hooker, Neil Z. Miller\",\"doi\":\"10.15761/jts.1000459\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Using survey data from respondents associated with three medical practices in the US, vaccinated children were compared to unvaccinated children for the incidence of severe allergies, autism, gastrointestinal disorders, asthma, ADHD, and chronic ear infections. All diagnoses were based on parental reporting with chart review for confirmation of diagnoses. Cases were stratified with non-cases based on year of birth and sex, and compared using a logistic regression model which also accounted for breastfeeding status and type of birth (vaginal versus cesarean section). Vaccinated children were significantly more likely than unvaccinated children to be diagnosed with severe allergies (OR = 4.31, 95% CI 1.67 - 11.1), autism (OR = 5.03, 95% CI 1.64 - 15.5), gastrointestinal disorders (OR = 13.8, 95% CI 5.85 - 32.5), asthma (OR = 17.6, 95% CI 6.94 - 44.4), ADHD (OR = 20.8, 95% CI 4.74 - 91.2), and chronic ear infections (OR = 27.8, 95% CI 9.56 - 80.8). Vaccinated children were less likely to be diagnosed with chickenpox (OR = 0.10, 95% CI 0.029\",\"PeriodicalId\":74000,\"journal\":{\"name\":\"Journal of translational science\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of translational science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15761/jts.1000459\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of translational science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15761/jts.1000459","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Health effects in vaccinated versus unvaccinated children, with covariates for breastfeeding status and type of birth
Using survey data from respondents associated with three medical practices in the US, vaccinated children were compared to unvaccinated children for the incidence of severe allergies, autism, gastrointestinal disorders, asthma, ADHD, and chronic ear infections. All diagnoses were based on parental reporting with chart review for confirmation of diagnoses. Cases were stratified with non-cases based on year of birth and sex, and compared using a logistic regression model which also accounted for breastfeeding status and type of birth (vaginal versus cesarean section). Vaccinated children were significantly more likely than unvaccinated children to be diagnosed with severe allergies (OR = 4.31, 95% CI 1.67 - 11.1), autism (OR = 5.03, 95% CI 1.64 - 15.5), gastrointestinal disorders (OR = 13.8, 95% CI 5.85 - 32.5), asthma (OR = 17.6, 95% CI 6.94 - 44.4), ADHD (OR = 20.8, 95% CI 4.74 - 91.2), and chronic ear infections (OR = 27.8, 95% CI 9.56 - 80.8). Vaccinated children were less likely to be diagnosed with chickenpox (OR = 0.10, 95% CI 0.029