F. Odabasoglu, O. Yildirim, Z. Halıcı, H. Aygun, M. Halici, Fadime Atalay, E. Çadırcı, I. Can, A. Cakir, Ozlem Aydin Berktas, A. Aslan, Y. Bayir, F. Erdoğan, B. Aksakal
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引用次数: 0
摘要
长叶青衣(Usnea longissima Ach .)是一种以保护作用闻名的地衣。在本研究中，我们观察了橄榄油和茴香酸对兔股骨钛植入后细胞凋亡的影响。我们确定地衣代谢物和橄榄油激活半胱天冬酶依赖性程序性细胞死亡，而不是坏死。口服和局部给药橄榄油和枸杞酸均通过激活caspase 2、3、8和9显示促凋亡作用。此外，它们还表现出较强的髓过氧化物酶(MPO)和诱导型一氧化氮合酶(iNOS)活性。然而，iNOS和MPO的活动在局部应用中没有很强的影响。SOD活性和GSH水平降低。同时，这些组织中钛的植入也减少了。根据获得的数据，usic酸和橄榄油均可诱导凋亡细胞死亡。因此，它可以作为促凋亡剂用于各种疾病的治疗。
The effect of usnic acid supplementation on rabbit’s tissues surrounding implant apoptosis and some enzyme activities
Usnea longissima Ach ., is a type of lichen known for its protective effects. In this study, we examined the effects of olive oil and usnic acid against apoptosis in rabbit femurs after titanium implantation. We determined that lichen metabolite and olive oil activate caspase-dependent programmatic cell death unlike necrosis. Both orally and locally administered olive oil and usnic acid showed proapoptotic effect through the activation of caspase 2, 3, 8 and 9. Also, they showed strong myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) activities. However, iNOS and MPO activities do not have a strong effect in local application. decreased SOD activity and GSH level. In parallel, titanium implantation in these tissues also decreased. In the light of the data obtained, both usnic acid and olive oil induced apoptotic cell death. Therefore, it can be used as a proapoptotic agent in the treatment of various diseases.
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